{"id":"W2040412126","doi":"10.1016/j.cell.2006.11.049","title":"p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; U.S. Department of Defense; University of Calgary; Austrian Science Fund; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; AstraZeneca; American Association for Cancer Research","keywords":"Proto-oncogene tyrosine-protein kinase Src; Cyclin-dependent kinase 2; Biology; Cyclin E; Cancer research; Cell biology; MCF-7; Cyclin-dependent kinase; Phosphorylation; Cyclin A; Cyclin D; Cell cycle; Cancer cell; Cancer; Biochemistry; Cell; Protein kinase A; Human breast; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271039,0.00008970763,0.0001503323,0.00007499412,0.00002287996,0.00000343614,0.0000262887,0.0001390741,0.0001682466],"category_scores_gemma":[0.00003249761,0.00009174851,0.00007050241,0.000181899,0.00004734667,0.00003300151,0.00001460689,0.0001308936,0.00006900916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009814214,"about_ca_system_score_gemma":0.00003700373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004386075,"about_ca_topic_score_gemma":0.000007748447,"domain_scores_codex":[0.9991978,0.00001119021,0.000262666,0.0001671452,0.0002009557,0.0001602074],"domain_scores_gemma":[0.9994875,0.00002817627,0.0001154088,0.0002088633,0.00008077846,0.00007924336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200622,0.0001082283,0.000379925,0.00005631457,0.00001003617,0.00001414381,0.0001488548,0.0000157116,0.9872578,0.0000310564,0.009249169,0.002608662],"study_design_scores_gemma":[0.00123211,0.0001509498,0.003108552,0.00008559365,0.0000499257,0.000007789094,0.00004937124,0.0001003927,0.9870467,0.0001495025,0.007937009,0.00008212664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746369,0.001703818,0.002886389,0.0001139486,0.0001662337,0.0002484309,0.000009141251,0.00005284829,0.02018236],"genre_scores_gemma":[0.9972701,0.00006757779,0.0006611113,0.0001334223,0.00006606878,0.000002392499,0.0001421055,0.00002238951,0.001634811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02263329,"threshold_uncertainty_score":0.3741396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006800998524122243,"score_gpt":0.2286949045392962,"score_spread":0.221893906015174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}