{"id":"W2040412126","doi":"10.1016/j.cell.2006.11.049","title":"p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; U.S. Department of Defense; University of Calgary; Austrian Science Fund; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; AstraZeneca; American Association for Cancer Research","keywords":"Proto-oncogene tyrosine-protein kinase Src; Cyclin-dependent kinase 2; Biology; Cyclin E; Cancer research; Cell biology; MCF-7; Cyclin-dependent kinase; Phosphorylation; Cyclin A; Cyclin D; Cell cycle; Cancer cell; Cancer; Biochemistry; Cell; Protein kinase A; Human breast; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586287,0.0002949763,0.000241576,0.0003491218,0.0003697738,0.0004469308,0.0003037146,0.000173011,0.002593245],"category_scores_gemma":[0.000230284,0.0001828707,0.0002782585,0.0002103906,0.0002759126,0.0002623396,0.0002934246,0.0005561723,0.0005773195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006710226,"about_ca_system_score_gemma":0.0004312494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001449629,"about_ca_topic_score_gemma":0.002475484,"domain_scores_codex":[0.9998426,0.0000201031,0.000009093494,0.00001813156,0.00002932948,0.00008068481],"domain_scores_gemma":[0.9999062,0.00002230636,0.00001738095,0.00001045841,0.00001574032,0.00002791347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007423165,0.0001117141,0.0007871934,0.00005626561,0.00001377169,0.0002810229,0.00003052848,0.0001140168,0.9932519,0.0009115559,0.0004194925,0.003280331],"study_design_scores_gemma":[0.00005440115,0.0001664975,0.01198278,0.000003967516,0.00001537182,0.0003844561,0.00006423203,0.001265877,0.982777,0.0001593203,0.003122421,0.000003757031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886985,0.003327012,0.00127133,0.000291278,0.00005359244,0.00002014178,0.0002382326,0.00007166373,0.00602814],"genre_scores_gemma":[0.9948546,0.001082489,0.0003691189,0.00004054475,0.00001769952,0.00001636568,0.0002844436,0.00001642992,0.00331829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002593245,"threshold_uncertainty_score":0.008675277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006800998524122243,"score_gpt":0.2286949045392962,"score_spread":0.221893906015174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}