{"id":"W2040417994","doi":"10.1186/2049-3002-2-s1-p82","title":"Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Vancouver General Hospital; University Health Network; Princess Margaret Cancer Centre; Occupational Cancer Research Centre","funders":"","keywords":"COPD; Lung; Medicine; Epigenetics; Lung cancer; DNA methylation; Inflammation; Disease; Pulmonary disease; Obstructive lung disease; Bioinformatics; Immunology; Pathology; Internal medicine; Oncology; Gene; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456308,0.000178215,0.0002850803,0.0007725114,0.0003427096,0.00044557,0.0001872158,0.0003060832,0.002841631],"category_scores_gemma":[0.0006684554,0.0001268962,0.0001759048,0.00039914,0.0003671304,0.0002166269,0.0004744557,0.0002560289,0.0005095971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001652798,"about_ca_system_score_gemma":0.0001254478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009696531,"about_ca_topic_score_gemma":0.0011588,"domain_scores_codex":[0.9998047,0.00002285167,0.00002246236,0.00004574872,0.00004494266,0.00005944681],"domain_scores_gemma":[0.9996569,0.00007811163,0.00008998905,0.00004322567,0.00005008101,0.00008170344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001997796,0.0001049193,0.5733181,0.00008839638,0.00007524179,0.002887464,0.001066769,0.00008268812,0.4108825,0.000557529,0.0002269591,0.008711595],"study_design_scores_gemma":[0.0000127515,0.0002504376,0.9816984,0.000005289376,0.00002677588,0.004983915,0.0005858498,0.0001112357,0.01142593,0.0001595733,0.000735286,0.000004541486],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981159,0.0003394532,0.0002531148,0.00003497606,0.000007196988,0.000009256444,0.000288291,0.00001002505,0.0009418547],"genre_scores_gemma":[0.998662,0.0001160661,0.0001333864,0.00003088586,0.000007238478,0.00001034778,0.0005702378,0.000006568057,0.0004633744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002841631,"threshold_uncertainty_score":0.009506166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004996237368249016,"score_gpt":0.2327628319541761,"score_spread":0.2277665945859271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}