{"id":"W2040419432","doi":"10.1128/mcb.00185-14","title":"Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mesenchymal stem cell; Osteoblast; Cell biology; Adipocyte; Bone morphogenetic protein 2; Cell fate determination; Transcription factor; Progenitor cell; Gene knockdown; RUNX2; Cellular differentiation; Adipose tissue; Stem cell; Cell culture; Genetics; Endocrinology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004101645,0.0002412077,0.0003030731,0.00005754814,0.0000791446,0.00001361927,0.000152603,0.0003043157,0.00003128186],"category_scores_gemma":[0.00008262036,0.0002204666,0.0001437336,0.00006585896,0.0001466509,0.000003289967,0.0001085823,0.0001080935,0.000004112061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001126497,"about_ca_system_score_gemma":0.00003165916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004707384,"about_ca_topic_score_gemma":0.00001902428,"domain_scores_codex":[0.9983429,0.0002917685,0.0003804981,0.0005450432,0.0001590664,0.0002807381],"domain_scores_gemma":[0.9991915,0.00002675212,0.0001664126,0.0004026746,0.00008637331,0.0001262446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003184272,0.0000997894,0.000364046,0.00003034167,0.0001002829,0.000003316839,0.00002578088,0.00004351584,0.9968101,0.0001932618,0.00003016508,0.001980979],"study_design_scores_gemma":[0.001780555,0.001152731,0.0001138872,0.00001635804,0.00006213589,0.000002406357,0.00001414103,0.0001333526,0.981002,0.0001137824,0.0153718,0.000236828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634091,0.01768627,0.01749492,0.00007690679,0.0001758845,0.0003413057,0.00007468367,0.00001238131,0.0007285037],"genre_scores_gemma":[0.9977562,0.0003860298,0.000495768,0.0000462578,0.00009389973,0.0000567418,0.0009222596,0.00003022838,0.0002125742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0343471,"threshold_uncertainty_score":0.8990366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937243105707406,"score_gpt":0.2248275146691847,"score_spread":0.2178902715634773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}