{"id":"W2040419432","doi":"10.1128/mcb.00185-14","title":"Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mesenchymal stem cell; Osteoblast; Cell biology; Adipocyte; Bone morphogenetic protein 2; Cell fate determination; Transcription factor; Progenitor cell; Gene knockdown; RUNX2; Cellular differentiation; Adipose tissue; Stem cell; Cell culture; Genetics; Endocrinology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230894,0.0004584813,0.0002408028,0.0001601553,0.0001697736,0.0002601448,0.0001947173,0.0002032534,0.001272588],"category_scores_gemma":[0.0001019048,0.0001753208,0.0002577596,0.0001038861,0.0002109685,0.0001179228,0.0002312269,0.000414006,0.0005867587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273169,"about_ca_system_score_gemma":0.0002224295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007907976,"about_ca_topic_score_gemma":0.00147741,"domain_scores_codex":[0.999877,0.00001318561,0.000009678267,0.00003438893,0.00003217231,0.00003356048],"domain_scores_gemma":[0.999905,0.0000134935,0.00003840306,0.000008661955,0.000006714864,0.00002783253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002093989,0.000004448868,0.0001161469,0.000007911586,0.000001209813,0.00002842141,0.000004277357,0.00001695869,0.999402,0.00003223151,0.0000087963,0.0003565576],"study_design_scores_gemma":[0.00001128468,0.00006261976,0.00499871,0.00000311028,0.000008205579,0.0001587608,0.00001312346,0.0007414827,0.9930633,0.0000268871,0.0009092285,0.000003465251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937942,0.0006660272,0.003939313,0.00005138584,0.000017372,0.00001445152,0.0002608914,0.0001161525,0.00114014],"genre_scores_gemma":[0.9962732,0.0003325959,0.001430509,0.00003785059,0.000005100156,0.00001651299,0.000383782,0.00002718347,0.001493376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272588,"threshold_uncertainty_score":0.004257262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937243105707406,"score_gpt":0.2248275146691847,"score_spread":0.2178902715634773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}