{"id":"W2040434984","doi":"10.1371/journal.pone.0115258","title":"Liganded Peroxisome Proliferator-Activated Receptors (PPARs) Preserve Nuclear Histone Deacetylase 5 Levels in Endothelin-Treated Sprague-Dawley Rat Cardiac Myocytes","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase 5; Histone deacetylase; Diacylglycerol kinase; Biology; Cell biology; Protein kinase C; Phosphorylation; Signal transduction; HDAC4; Mef2; Nuclear export signal; Histone; Transcription factor; Biochemistry; Cell nucleus; Cytoplasm; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003736165,0.000387849,0.0005218979,0.0001030616,0.0001021756,0.00005649422,0.0003972314,0.0003337867,0.000127058],"category_scores_gemma":[0.001009708,0.0004025899,0.000161268,0.0002172935,0.000133752,0.00001700139,0.0001884508,0.0002632658,0.0001021339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001085549,"about_ca_system_score_gemma":0.0001154876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006687873,"about_ca_topic_score_gemma":0.00002014671,"domain_scores_codex":[0.9975083,0.0003859753,0.0004418784,0.0007550126,0.000374704,0.0005341593],"domain_scores_gemma":[0.9984636,0.00006527473,0.0001640718,0.0008153451,0.0002059202,0.0002858344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004681362,0.001175348,0.01320501,0.0000946717,0.0002886588,0.000008949675,0.0001209569,0.00002584145,0.9837277,0.00002253951,0.0007495411,0.0001126731],"study_design_scores_gemma":[0.001562686,0.0003966948,0.0008356063,0.0001495068,0.0001075963,0.000001267175,0.00003630483,0.0001313381,0.9947855,0.00002983428,0.001493974,0.0004697103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976668,0.0007132113,0.000008366123,0.0001440507,0.0001646236,0.0006986713,0.00010222,0.0001225464,0.0003795387],"genre_scores_gemma":[0.99739,0.00009848653,0.0006238418,0.0002304983,0.0003802472,0.0001313704,0.0001921063,0.0001279574,0.0008255349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01236941,"threshold_uncertainty_score":0.9998426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02891620277093261,"score_gpt":0.238247078611782,"score_spread":0.2093308758408493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}