{"id":"W2040456254","doi":"10.1063/1.3463720","title":"Gold nanoparticle-assisted single base-pair mismatch discrimination on a microfluidic microarray device","year":2010,"lang":"en","type":"article","venue":"Biomicrofluidics","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Amplicon; Microfluidics; Colloidal gold; DNA; Nanotechnology; Botrytis; Materials science; Biosensor; DNA microarray; Base pair; Nanoparticle; DNA–DNA hybridization; Molecule; Polymerase chain reaction; Analytical Chemistry (journal); Chemistry; Chromatography; Botrytis cinerea; Biology; Biochemistry; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004903371,0.0006538234,0.0007907079,0.0005003647,0.0003103826,0.0004422566,0.001259814,0.0007730471,0.0008282674],"category_scores_gemma":[0.0004359145,0.0005572296,0.0003041296,0.000206032,0.0003807959,0.0004254636,0.0005352086,0.0004871494,0.0005626638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007185418,"about_ca_system_score_gemma":0.0004102814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005040601,"about_ca_topic_score_gemma":0.0007972213,"domain_scores_codex":[0.9994492,0.00007347411,0.00004240243,0.000202606,0.0001709328,0.0000612886],"domain_scores_gemma":[0.9997416,0.0001184714,0.00003358379,0.00003676552,0.00003696536,0.00003263376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007276864,0.00002594836,0.0001232642,0.0001088311,0.000009461778,0.00005382757,0.00002329264,0.0003233537,0.992086,0.0003331482,0.000358454,0.006481665],"study_design_scores_gemma":[0.00003304689,0.0001239841,0.0009221872,0.00001084894,0.0000179963,0.0001559591,0.000008373,0.009761841,0.9838189,0.0001637976,0.004932417,0.00005059679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.554065,0.003663574,0.4261006,0.001532063,0.001476361,0.0008815163,0.002049419,0.006306543,0.003924808],"genre_scores_gemma":[0.4871761,0.00134724,0.5032444,0.0006809246,0.0002387665,0.0008916204,0.000633181,0.00008860476,0.005699072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259814,"threshold_uncertainty_score":0.005213439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109993527753308,"score_gpt":0.2696094625478513,"score_spread":0.2485095272703182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}