{"id":"W2040472577","doi":"10.1177/1091581814529309","title":"Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy","year":2014,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Mitochondrial toxicity; Toxicity; Pharmacology; Medicine; Reverse transcriptase; Lactic acidosis; Nucleoside analogue; Lipodystrophy; Nucleoside Reverse Transcriptase Inhibitor; Zidovudine; Nucleoside; Internal medicine; Immunology; Biology; Viral load; Virus; Antiretroviral therapy; Biochemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000821477,0.0004658345,0.0006237342,0.0002431204,0.0002476049,0.0005301511,0.0003289497,0.0004458731,0.002904993],"category_scores_gemma":[0.0009260516,0.000110729,0.0003683422,0.0002490539,0.0002566514,0.0002612919,0.000133251,0.0009067117,0.0007688517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003619001,"about_ca_system_score_gemma":0.000613397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003373388,"about_ca_topic_score_gemma":0.0007249947,"domain_scores_codex":[0.9995602,0.0001639033,0.00003139489,0.00006035697,0.0001496664,0.00003450393],"domain_scores_gemma":[0.9993463,0.0001278062,0.0001428722,0.00007171421,0.0001657942,0.00014553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05241195,0.01049306,0.01557219,0.0007748877,0.0004808328,0.001204765,0.0002980169,0.001726398,0.5675338,0.0009464634,0.005246652,0.343311],"study_design_scores_gemma":[0.0130117,0.542255,0.08077324,0.0002528703,0.0008744559,0.009525254,0.0003215822,0.007821916,0.2540833,0.001299362,0.08971571,0.0000655408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792737,0.007395721,0.003209377,0.0004619349,0.0001252675,0.0005778465,0.001032571,0.0001991281,0.007724453],"genre_scores_gemma":[0.9907668,0.002595594,0.001354696,0.0003503536,0.0001050601,0.0002734441,0.001754447,0.0000351619,0.002764501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904993,"threshold_uncertainty_score":0.00971812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234577583511188,"score_gpt":0.3265876299972269,"score_spread":0.304241854162115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}