{"id":"W2040472577","doi":"10.1177/1091581814529309","title":"Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy","year":2014,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Mitochondrial toxicity; Toxicity; Pharmacology; Medicine; Reverse transcriptase; Lactic acidosis; Nucleoside analogue; Lipodystrophy; Nucleoside Reverse Transcriptase Inhibitor; Zidovudine; Nucleoside; Internal medicine; Immunology; Biology; Viral load; Virus; Antiretroviral therapy; Biochemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006313581,0.0001124784,0.000394313,0.0002815868,0.0000284636,0.000008610677,0.0001685138,0.0001178587,0.0002310985],"category_scores_gemma":[0.0003744843,0.00008666585,0.0002589183,0.00006795642,0.00008025182,0.00007333726,0.00001587136,0.0001633621,0.000008146018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407839,"about_ca_system_score_gemma":0.0001920502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001542429,"about_ca_topic_score_gemma":0.000003477929,"domain_scores_codex":[0.9984717,0.00007628456,0.0008265404,0.0001231068,0.0003686647,0.0001337434],"domain_scores_gemma":[0.998419,0.0002765099,0.0004619926,0.0000824072,0.0006680836,0.00009198263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05768352,0.01453503,0.1159414,0.0001708617,0.00577562,0.0003550463,0.00325434,0.00005103619,0.3050186,0.03487144,0.07380232,0.3885408],"study_design_scores_gemma":[0.09419759,0.01991896,0.1173534,0.0006049135,0.0005365393,0.001115285,0.0003040893,0.002977601,0.2618577,0.006206483,0.4943957,0.0005316945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706231,0.0001024419,0.003585733,0.02204893,0.001656142,0.0004454,0.00003858991,0.00001179692,0.001487864],"genre_scores_gemma":[0.9875938,0.00006991606,0.009470376,0.0007283956,0.0005014861,0.00001407678,0.00004145332,0.00001513682,0.001565385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4205934,"threshold_uncertainty_score":0.3534131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234577583511188,"score_gpt":0.3265876299972269,"score_spread":0.304241854162115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}