{"id":"W2040516491","doi":"10.1038/srep05715","title":"Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre hospitalier de l'Université Laval; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Leupeptin; Secretion; Biology; Antibody; Tau protein; Internal medicine; Cell biology; Endocrinology; Neuroscience; Chemistry; Biochemistry; Alzheimer's disease; Immunology; Medicine; Protease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851887,0.0006756068,0.0008517749,0.0002623511,0.0002223163,0.0004415458,0.000234907,0.0002856633,0.0009961491],"category_scores_gemma":[0.0001861707,0.0001680631,0.0004643062,0.0002432206,0.000242955,0.0001885258,0.000344007,0.0005839365,0.0003279815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005623624,"about_ca_system_score_gemma":0.0007841834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002753907,"about_ca_topic_score_gemma":0.005761636,"domain_scores_codex":[0.9997826,0.00002792515,0.00003567664,0.00004108134,0.00005205127,0.000060699],"domain_scores_gemma":[0.9998655,0.00003266792,0.00002187253,0.00001661662,0.00002664997,0.00003654425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004341423,0.00003728024,0.0001529382,0.00008605581,0.00001187497,0.0001017771,0.00003480632,0.00004624842,0.9979539,0.00003026157,0.00005899185,0.001051714],"study_design_scores_gemma":[0.0000309504,0.0004608024,0.00588516,0.00001372993,0.00002908799,0.0002343606,0.0000596848,0.0005547518,0.9911679,0.00005847661,0.001495688,0.00000940853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918188,0.003767714,0.001340554,0.0001563209,0.00006739919,0.0000444324,0.0007458878,0.0001097462,0.001949075],"genre_scores_gemma":[0.9905002,0.002533264,0.002441675,0.00008671924,0.00002037784,0.000104615,0.0008601876,0.00002939949,0.003423566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002753907,"threshold_uncertainty_score":0.00547576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337149793298408,"score_gpt":0.254963259829385,"score_spread":0.2415917618964009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}