{"id":"W2040524570","doi":"10.1016/j.mad.2008.09.017","title":"The age-related decrease in catecholamine sensitivity is mediated by ß1-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats","year":2008,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Endocrinology; Internal medicine; Forskolin; Agonist; Catecholamine; Stimulation; Adenylate kinase; Cyclase; Myocyte; Receptor; Contraction (grammar); Phosphodiesterase; Adrenergic receptor; Biology; Adrenergic; Chemistry; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004985252,0.0001893339,0.0002173105,0.0001439722,0.0001028382,0.00001553599,0.00006727727,0.0002121607,0.00003087305],"category_scores_gemma":[0.0003603504,0.0001643429,0.00003431754,0.0002782398,0.00003863904,0.00001153151,0.00009073238,0.0001419387,0.000004104683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006817707,"about_ca_system_score_gemma":0.0001474154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008523969,"about_ca_topic_score_gemma":0.0007877159,"domain_scores_codex":[0.9986659,0.0001844679,0.0003438625,0.0003799581,0.0001761395,0.0002496752],"domain_scores_gemma":[0.9994628,0.00005730093,0.00009933444,0.0001587118,0.00004632049,0.0001754935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006054411,0.0002930406,0.004363437,0.00001112834,0.00004548777,0.0005666274,0.0009064495,0.0007235731,0.9865007,0.000006739398,0.0004404764,0.00553688],"study_design_scores_gemma":[0.001837954,0.00008926122,0.08693498,0.00008745246,0.000006326275,0.0000192146,0.0001202964,0.001483577,0.9069789,0.00007220152,0.00206196,0.0003078522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976904,0.0002603614,0.001394694,0.0002283563,0.0001244664,0.0002590546,0.00001171693,0.00001099563,0.00001996387],"genre_scores_gemma":[0.9980359,0.0001960532,0.0009290446,0.0002070207,0.00001511449,0.0000365141,0.0002368961,0.00001561887,0.0003278133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08257154,"threshold_uncertainty_score":0.6701708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005470749853727,"score_gpt":0.2100755372801968,"score_spread":0.2000208297816595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}