{"id":"W2040527067","doi":"10.1073/pnas.1014660108","title":"Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC","keywords":"DNA methylation; Methylation; Gene silencing; Biology; Methyltransferase; Endogenous retrovirus; Retrovirus; Murine leukemia virus; Histone H3; Molecular biology; DNA; Genetics; Gene; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260164,0.0005867363,0.0003694434,0.0002994279,0.0002242117,0.000414095,0.000415162,0.000493933,0.001401538],"category_scores_gemma":[0.0001536925,0.0002807565,0.0003643328,0.0002162051,0.0003483702,0.0002163142,0.0004655575,0.0006116952,0.001058885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004377918,"about_ca_system_score_gemma":0.0003380373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285295,"about_ca_topic_score_gemma":0.001901326,"domain_scores_codex":[0.9997798,0.0000314654,0.00002868041,0.00005776719,0.00005758645,0.00004474929],"domain_scores_gemma":[0.999725,0.00004225688,0.0000915885,0.00004365958,0.00001473441,0.00008261116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000457408,0.000008982614,0.0001733641,0.00001276905,0.000003762878,0.00005710468,0.000003913476,0.00002379292,0.9992866,0.00004092417,0.00001356545,0.0003294896],"study_design_scores_gemma":[0.00001654925,0.0001034478,0.01006243,0.000005202513,0.00001717592,0.0004032959,0.00002227228,0.0009574703,0.986295,0.00006925475,0.002041256,0.000006646005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938785,0.00121338,0.002454051,0.0001102348,0.00003746108,0.00002736454,0.001078973,0.0002525046,0.0009474767],"genre_scores_gemma":[0.9940326,0.0004669725,0.001642685,0.00005844177,0.000007958863,0.00002767598,0.001670562,0.00007812688,0.002015017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401538,"threshold_uncertainty_score":0.004688621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03235998313547288,"score_gpt":0.308680346199615,"score_spread":0.2763203630641421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}