{"id":"W2040527067","doi":"10.1073/pnas.1014660108","title":"Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC","keywords":"DNA methylation; Methylation; Gene silencing; Biology; Methyltransferase; Endogenous retrovirus; Retrovirus; Murine leukemia virus; Histone H3; Molecular biology; DNA; Genetics; Gene; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001589204,0.00006543771,0.00009645476,0.00003811439,0.0001068923,0.000009821777,0.0003542322,0.00005076189,0.000001652965],"category_scores_gemma":[0.0004564265,0.00003323018,0.00006715586,0.0001739093,0.0005986419,0.00001909503,0.00006069091,0.00005105038,2.352552e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005673107,"about_ca_system_score_gemma":0.00002632072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001251518,"about_ca_topic_score_gemma":2.322073e-7,"domain_scores_codex":[0.9992689,0.000007011619,0.0002105848,0.0001439086,0.0002607792,0.0001087941],"domain_scores_gemma":[0.9995639,0.00006406551,0.0001592203,0.00001359669,0.0001844051,0.00001476634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008559709,0.00000943251,0.000306267,0.00004265224,0.00002047536,8.120787e-10,0.0005554393,0.00004605395,0.9922024,0.006149326,0.00007276028,0.0005095763],"study_design_scores_gemma":[0.0003698379,0.00005977502,0.003999658,0.00001993114,0.00002514874,0.000003237587,0.0003720611,0.001143011,0.9874142,0.006465198,0.00008516534,0.00004276239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996705,0.0002565532,0.0006608497,0.001481666,0.0000125764,0.0002757091,0.00002230391,0.000001922743,0.0005834277],"genre_scores_gemma":[0.9967257,0.00009047791,0.002827251,0.0002149598,0.00004471457,0.00002122972,2.457022e-7,0.000003295227,0.00007213376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004788205,"threshold_uncertainty_score":0.2205721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03235998313547288,"score_gpt":0.308680346199615,"score_spread":0.2763203630641421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}