{"id":"W2040537103","doi":"10.1152/ajpcell.00357.2009","title":"Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Sirtuin 1; Nicotinamide phosphoribosyltransferase; Cell biology; Biology; Senescence; Endothelial stem cell; Matrigel; Endothelial dysfunction; Cell; NAD+ kinase; Genetics; Gene; Biochemistry; Endocrinology; Downregulation and upregulation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152208,0.0002756597,0.000208736,0.0001682427,0.00009386407,0.0002044568,0.000145049,0.000232405,0.0009227885],"category_scores_gemma":[0.0001514086,0.0001561368,0.0001846162,0.00010669,0.0001183187,0.0001433994,0.0001732348,0.0003428619,0.0002155286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778994,"about_ca_system_score_gemma":0.0001405726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007475609,"about_ca_topic_score_gemma":0.0005682102,"domain_scores_codex":[0.9999003,0.00002005736,0.00001494052,0.00002457925,0.00002258127,0.00001763897],"domain_scores_gemma":[0.999884,0.00001764806,0.00004248015,0.00001826179,0.000008717137,0.00002890699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001405873,0.00002470779,0.0001058486,0.00001870639,0.000005778192,0.00005096891,0.000009988087,0.00003849251,0.9984789,0.0000308835,0.00001967025,0.001075488],"study_design_scores_gemma":[0.00004464093,0.001316207,0.01162761,0.00001056437,0.00002746838,0.0007314762,0.000034372,0.001600653,0.9822782,0.0001054289,0.002216343,0.000007054732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994859,0.001977582,0.001991766,0.00007292396,0.00001776208,0.00002425897,0.000288212,0.00009304444,0.0006753764],"genre_scores_gemma":[0.9963931,0.000875243,0.0008707722,0.00005102597,0.000004381462,0.00002890381,0.0003695077,0.0000133726,0.001393634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009227885,"threshold_uncertainty_score":0.003087044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003965026205630513,"score_gpt":0.2418619365723869,"score_spread":0.2378969103667563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}