{"id":"W2040547343","doi":"10.1038/nature10251","title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":2739,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; Helmholtz Zentrum München; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Haukeland Universitetssjukehus; Vlaamse regering; Norges Forskningsråd; Stockholms Läns Landsting; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Fondazione CRT; Hjärnfonden; Institut National de la Santé et de la Recherche Médicale; Multiple Sclerosis Australia; Helsingin ja Uudenmaan Sairaanhoitopiiri; Multiple Sclerosis Society; Ministero della Salute; Forskningsrådet för Arbetsliv och Socialvetenskap; National Institute for Health and Care Research; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Wellcome Trust; Parkinson's UK; Institute of Clinical and Translational Sciences; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Regione Piemonte; Deutsche Forschungsgemeinschaft; Biogen; Fogarty International Center; Fonds Wetenschappelijk Onderzoek; Susan G. Komen for the Cure; Academy of Finland; Children's Hospital of Philadelphia; Scleroseforeningen; U.S. Public Health Service; Kaiser Permanente","keywords":"Multiple sclerosis; Primary (astronomy); Immune system; Biology; Neuroscience; Genetics; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004094279,0.0005553058,0.0004451845,0.0008345008,0.000295003,0.0006230171,0.0003863933,0.0008634322,0.003407643],"category_scores_gemma":[0.00141414,0.0001964009,0.0002637028,0.0004722461,0.0006213451,0.0004689479,0.0004253867,0.0008011704,0.0002573777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190484,"about_ca_system_score_gemma":0.0003293247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004327214,"about_ca_topic_score_gemma":0.0003530688,"domain_scores_codex":[0.9995915,0.0001635385,0.00003225728,0.00007707657,0.00008633525,0.00004924017],"domain_scores_gemma":[0.999196,0.0003179637,0.0002705682,0.00007537752,0.00004494426,0.00009510473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008973289,0.0008934884,0.395245,0.0005110669,0.0006982605,0.01703062,0.001048144,0.002439857,0.4605379,0.03126498,0.002150191,0.07920709],"study_design_scores_gemma":[0.0004085525,0.001770135,0.8359675,0.0002974047,0.001207488,0.03331369,0.0008813843,0.006239576,0.0631876,0.04609609,0.01054104,0.0000895527],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852698,0.007077541,0.001540794,0.001794031,0.00006962656,0.000009523708,0.0001691492,0.00004151232,0.004028036],"genre_scores_gemma":[0.9960051,0.002043882,0.0007512509,0.0001145319,0.0001407256,0.000007970109,0.00005620761,0.000008511449,0.0008716924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003407643,"threshold_uncertainty_score":0.01139975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032469319244916,"score_gpt":0.2217452417452889,"score_spread":0.2014205485528398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}