{"id":"W2040574121","doi":"10.1186/s13395-015-0038-6","title":"Wnt/β-catenin controls follistatin signalling to regulate satellite cell myogenic potential","year":2015,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Ministero dello Sviluppo Economico; Stem Cell Network; Muscular Dystrophy Canada; E-Rare; Ontario Ministry of Economic Development and Innovation; Natural Sciences and Engineering Research Council of Canada; Muscular Dystrophy Association","keywords":"Myogenin; Myogenesis; Follistatin; Wnt signaling pathway; Cell biology; Myocyte; Biology; Beta-catenin; MyoD; LRP6; Skeletal muscle; Cellular differentiation; Catenin; C2C12; Endocrinology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121496,0.0003506099,0.0001751838,0.000266681,0.000182779,0.0004754014,0.0001986214,0.0002913737,0.001573938],"category_scores_gemma":[0.0001298592,0.0002038611,0.0002192264,0.0001613715,0.0002640107,0.0002967372,0.0002698455,0.0003650485,0.0005863087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006770555,"about_ca_system_score_gemma":0.000292386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009547039,"about_ca_topic_score_gemma":0.002047617,"domain_scores_codex":[0.9998589,0.000016416,0.00001153616,0.00003347472,0.00003528403,0.00004437989],"domain_scores_gemma":[0.9998959,0.0000106283,0.00003818778,0.000007153088,0.00001760698,0.00003050362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006782936,0.000006116098,0.0003922519,0.00002257616,0.000003123607,0.00004710363,0.00001173828,0.00003836945,0.9987507,0.0001222899,0.00002200262,0.000515926],"study_design_scores_gemma":[0.00003752914,0.0001353775,0.02859753,0.00002256184,0.00002899612,0.0003262071,0.00008796153,0.002158531,0.9645109,0.0001695732,0.003917104,0.000007864426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906061,0.003385619,0.002838121,0.0001046965,0.00003000424,0.00002832288,0.0002903149,0.00007991475,0.002636904],"genre_scores_gemma":[0.994105,0.0008165598,0.000917569,0.00004444182,0.000004713997,0.00001657805,0.0003000714,0.00001553104,0.003779513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573938,"threshold_uncertainty_score":0.005265415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053420411144131,"score_gpt":0.2351514185217679,"score_spread":0.2246172144103266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}