{"id":"W2040577132","doi":"10.1159/000053989","title":"Optimization Strategies for DNA Vaccines","year":2000,"lang":"en","type":"article","venue":"Intervirology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Medical Research Council","keywords":"DNA vaccination; Immune system; Immunization; Biology; DNA; Antigen; Vaccination; Immunology; Plasmid; Virology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000627992,0.000902804,0.0006722593,0.000844119,0.0004316769,0.0008542393,0.0004934343,0.0006681924,0.003458961],"category_scores_gemma":[0.001122445,0.0004583904,0.0005836642,0.0006522161,0.0006054992,0.001104717,0.0005906398,0.001097045,0.001094674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009334575,"about_ca_system_score_gemma":0.0004673722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003601306,"about_ca_topic_score_gemma":0.0006840925,"domain_scores_codex":[0.9996043,0.0001072305,0.00002683287,0.00007420454,0.0001441495,0.00004324962],"domain_scores_gemma":[0.99977,0.0001069728,0.00005300656,0.00002208755,0.00003741529,0.00001046104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003159579,0.0003520794,0.001263633,0.00199813,0.0001716656,0.0003791047,0.0002697176,0.1979201,0.256817,0.2115189,0.004888349,0.3241055],"study_design_scores_gemma":[0.0002742864,0.001690612,0.00122936,0.0005926564,0.0003047032,0.001118096,0.0002897401,0.2530543,0.3082322,0.1676052,0.2654659,0.0001428359],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.08448603,0.0321117,0.8328582,0.001664087,0.0003967838,0.0006648573,0.0002306425,0.0005499836,0.04703769],"genre_scores_gemma":[0.4091791,0.03188383,0.5320438,0.0008284213,0.0001753217,0.00140648,0.0005083531,0.0003255319,0.02364913],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003458961,"threshold_uncertainty_score":0.01157135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150891890579049,"score_gpt":0.2518679389409324,"score_spread":0.2403590200351419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}