{"id":"W2040577132","doi":"10.1159/000053989","title":"Optimization Strategies for DNA Vaccines","year":2000,"lang":"en","type":"article","venue":"Intervirology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Medical Research Council","keywords":"DNA vaccination; Immune system; Immunization; Biology; DNA; Antigen; Vaccination; Immunology; Plasmid; Virology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001285149,0.0001397514,0.0002128632,0.00007709286,0.0001311393,0.00001893847,0.0002150194,0.0002335738,0.02337775],"category_scores_gemma":[0.00002085256,0.0001214725,0.0001065561,0.00005485872,0.0001065727,0.0001404507,0.0000167873,0.0001084399,0.0005291591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001137935,"about_ca_system_score_gemma":0.00003498963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002929255,"about_ca_topic_score_gemma":0.00001092969,"domain_scores_codex":[0.9990959,0.0001626931,0.0002462403,0.0001988104,0.000009697648,0.0002866181],"domain_scores_gemma":[0.9995244,0.000165309,0.00005133867,0.0002121508,0.00004023502,0.000006631827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0131655,0.0004828698,0.0001992251,0.00004951756,0.0009020539,0.000005829345,0.002333287,0.005672627,0.5809119,0.006300284,0.02013975,0.3698372],"study_design_scores_gemma":[0.005413608,0.002286849,0.002220426,0.00002889186,0.00007356334,0.0002838563,0.0006276243,0.0006760049,0.08581219,0.002649081,0.8994622,0.000465681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730261,0.005938247,0.01397791,0.001297892,0.0009594627,0.0003739352,0.00002774234,0.000172159,0.004226548],"genre_scores_gemma":[0.9855527,0.0002931066,0.0004046748,0.001077785,0.00004327473,0.000101296,0.0001175078,0.00002353163,0.01238607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8793225,"threshold_uncertainty_score":0.977515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150891890579049,"score_gpt":0.2518679389409324,"score_spread":0.2403590200351419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}