{"id":"W2040603020","doi":"10.1155/2010/465824","title":"ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy","year":2010,"lang":"en","type":"article","venue":"Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Diabetes Association","keywords":"KLF2; Gene knockdown; Diabetic retinopathy; Medicine; Vascular endothelial growth factor; MEF2C; Angiogenesis; Downregulation and upregulation; Endocrinology; Vascular endothelial growth factor A; Internal medicine; MAPK/ERK pathway; Cell biology; Cancer research; Signal transduction; Diabetes mellitus; Gene expression; Biology; VEGF receptors; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395516,0.000253582,0.0001372796,0.0001888932,0.0001478509,0.0002335051,0.0001315297,0.0002169266,0.0009371427],"category_scores_gemma":[0.0001058013,0.0001087033,0.0002504395,0.00009591784,0.0001432783,0.0001331965,0.0001753464,0.0003280656,0.0001792575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216903,"about_ca_system_score_gemma":0.0001292407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003433884,"about_ca_topic_score_gemma":0.0003225371,"domain_scores_codex":[0.9999208,0.0000148648,0.000008159429,0.000013631,0.00001870159,0.00002384593],"domain_scores_gemma":[0.9999403,0.000004905364,0.0000255024,0.000004655489,0.000008632523,0.00001603131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006472389,0.0001217646,0.002364309,0.0001496776,0.00002119427,0.0004562804,0.00002259167,0.0001210379,0.9882067,0.0004411568,0.0001139902,0.007334128],"study_design_scores_gemma":[0.0001075963,0.0007775365,0.1034033,0.00005181301,0.0001675437,0.003667072,0.0001452313,0.00380117,0.8799506,0.0008530647,0.007054372,0.00002068475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927173,0.004322364,0.001178822,0.0001094144,0.00002377745,0.00001439162,0.00009319161,0.00002946963,0.001511248],"genre_scores_gemma":[0.9972692,0.001094162,0.0004121762,0.00005301499,0.000007019592,0.000007117443,0.0001179163,0.000003885562,0.001035476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009371427,"threshold_uncertainty_score":0.003135026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0060352913464906,"score_gpt":0.2641593721342397,"score_spread":0.2581240807877491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}