{"id":"W2040633750","doi":"10.1016/j.joca.2008.02.013","title":"Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage","year":2008,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Aggrecan; ADAMTS; Aggrecanase; Chemistry; Keratan sulfate; Molecular biology; Edman degradation; Gel electrophoresis; Cartilage; Cleavage (geology); Metalloproteinase; Biochemistry; Thrombospondin; Chondroitin sulfate; Peptide sequence; Biology; Matrix metalloproteinase; Glycosaminoglycan; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003325114,0.0003092109,0.0002525356,0.000266784,0.0001972885,0.0002897641,0.0002692914,0.0003311195,0.001639203],"category_scores_gemma":[0.0003836839,0.0001976558,0.0005311103,0.000143403,0.0002986897,0.0002556918,0.000146952,0.0004573571,0.0005255062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489477,"about_ca_system_score_gemma":0.0002064567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555219,"about_ca_topic_score_gemma":0.001206093,"domain_scores_codex":[0.9997975,0.00003555774,0.00002669776,0.00004166861,0.00004445285,0.00005407774],"domain_scores_gemma":[0.9995677,0.0001098271,0.0001183805,0.00004537186,0.00007208229,0.00008665588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002392185,0.00001343389,0.0002179516,0.00002925062,0.000006179439,0.0001099149,0.00002307125,0.00003779355,0.9989121,0.00005113034,0.0000108669,0.0003491671],"study_design_scores_gemma":[0.00001443925,0.000170011,0.007199584,0.000009751794,0.00002408451,0.0004160559,0.0000499365,0.0005092002,0.9905021,0.00003332756,0.00106618,0.000005361322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937037,0.001144556,0.003966154,0.00006673585,0.00003593581,0.0000218326,0.0003657289,0.00001745817,0.0006779542],"genre_scores_gemma":[0.9923455,0.000338611,0.004138161,0.00005763962,0.0000139182,0.00001569325,0.00123691,0.0000153125,0.001838181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639203,"threshold_uncertainty_score":0.005483747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011120033053817,"score_gpt":0.2227838211346777,"score_spread":0.2126726208041395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}