{"id":"W2040663379","doi":"10.1016/j.jsbmb.2005.05.014","title":"Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment","year":2005,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Barbara Ann Karmanos Cancer Institute; Susan G. Komen; Susan G. Komen for the Cure","keywords":"MCF-7; Internal medicine; Endocrinology; Receptor; Cycloheximide; Cell growth; Biology; Cell culture; Hormone; Cancer cell; Biochemistry; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705819,0.0003288249,0.0004320078,0.0005555358,0.0004624464,0.0006459201,0.0002670117,0.0003842037,0.003192694],"category_scores_gemma":[0.0002464891,0.000399756,0.0004430274,0.0005822673,0.000325573,0.0003891159,0.0002024685,0.000611783,0.001795044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000775745,"about_ca_system_score_gemma":0.0003138022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005897755,"about_ca_topic_score_gemma":0.004752804,"domain_scores_codex":[0.9996141,0.00004819078,0.00002294615,0.00003915059,0.0001402831,0.0001353585],"domain_scores_gemma":[0.9998134,0.00005528985,0.00002618853,0.00003020581,0.00003513941,0.00003978985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522373,0.00002050163,0.0003212579,0.00003425999,0.000008306881,0.0001015147,0.00007229981,0.00002857628,0.9980382,0.000232713,0.0001553318,0.0008348114],"study_design_scores_gemma":[0.00003193955,0.000280301,0.03415191,0.00001761271,0.00004457276,0.001262725,0.0004288141,0.0008451428,0.9545545,0.0002235876,0.008134883,0.0000238841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834301,0.006380909,0.001928498,0.0005426944,0.0001047399,0.00002020892,0.002523043,0.0001327587,0.004937049],"genre_scores_gemma":[0.9758264,0.004206909,0.001687214,0.0001825622,0.00002979947,0.00004232856,0.005921503,0.00003761865,0.01206561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005897755,"threshold_uncertainty_score":0.01172686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002709960028682902,"score_gpt":0.2072637386292181,"score_spread":0.2045537786005352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}