{"id":"W2040665096","doi":"10.1016/j.placenta.2011.04.011","title":"mRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation","year":2011,"lang":"en","type":"article","venue":"Placenta","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia; St. Paul's Hospital","funders":"Canadian Institutes of Health Research; National Sanitarium Association","keywords":"Trophoblast; TLR3; Messenger RNA; Cell biology; Molecular biology; Chemistry; Biology; Receptor; Toll-like receptor; Placenta; Fetus; Biochemistry; Innate immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004079043,0.0002349209,0.0003261735,0.0002005215,0.0001390127,0.00001741215,0.0001950511,0.0002417345,0.0006978211],"category_scores_gemma":[0.00006298257,0.0002186286,0.00006807482,0.0001891395,0.0001161777,0.0004011513,0.0000566026,0.0002829004,0.0003318743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000959331,"about_ca_system_score_gemma":0.00006411568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382393,"about_ca_topic_score_gemma":0.0001412152,"domain_scores_codex":[0.9980746,0.0004472718,0.0004580782,0.0005967866,0.00005926324,0.0003640281],"domain_scores_gemma":[0.9992128,0.00003650453,0.0002390953,0.0003893401,0.00009790614,0.00002432436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003156069,0.0002083156,0.009345333,0.00005609204,0.00007326418,0.00000611995,0.005822206,0.00002911036,0.981028,0.00002461626,0.0001200124,0.002971325],"study_design_scores_gemma":[0.00109588,0.0001159196,0.01150948,0.000202338,0.00004568285,0.000106782,0.0005975472,0.00002122135,0.9855499,0.0001206701,0.0003728187,0.0002617741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918782,0.003766405,0.0002808653,0.00005099829,0.002699848,0.0006519047,0.00001226885,0.00006051658,0.0005990683],"genre_scores_gemma":[0.998185,0.00008455556,0.0004807667,0.00001291532,0.0001558587,0.0000135126,0.00005658925,0.00002484825,0.0009859495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006306879,"threshold_uncertainty_score":0.8915417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963154682161669,"score_gpt":0.2168887973025634,"score_spread":0.1872572504809467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}