{"id":"W2040665096","doi":"10.1016/j.placenta.2011.04.011","title":"mRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation","year":2011,"lang":"en","type":"article","venue":"Placenta","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia; St. Paul's Hospital","funders":"Canadian Institutes of Health Research; National Sanitarium Association","keywords":"Trophoblast; TLR3; Messenger RNA; Cell biology; Molecular biology; Chemistry; Biology; Receptor; Toll-like receptor; Placenta; Fetus; Biochemistry; Innate immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003678267,0.0003932924,0.0003521734,0.0001614328,0.0001894094,0.0004475494,0.0001563294,0.0003686805,0.001408292],"category_scores_gemma":[0.0002699441,0.0001863059,0.0004037911,0.0001190146,0.0003359916,0.0002390531,0.0003383944,0.000861562,0.0004980096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064814,"about_ca_system_score_gemma":0.0003230673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004009481,"about_ca_topic_score_gemma":0.0006788058,"domain_scores_codex":[0.9996963,0.00008378574,0.00002972779,0.00004769081,0.00005092856,0.0000916757],"domain_scores_gemma":[0.9997771,0.00009334458,0.00004417897,0.00003662049,0.00002356374,0.00002507256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499851,0.00001513395,0.00005357351,0.00002260436,0.000002798839,0.00004001511,0.00001980025,0.00003202519,0.9991438,0.0000714399,0.00002074757,0.0004281422],"study_design_scores_gemma":[0.00001660781,0.0001594981,0.0005475003,0.000003502625,0.000009183185,0.00004526407,0.00001964511,0.0003263115,0.9981369,0.00002260142,0.0007103454,0.000002690678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909895,0.0008023314,0.004775576,0.0002256978,0.0000830169,0.0000469699,0.0003006996,0.00008896616,0.002687166],"genre_scores_gemma":[0.9929082,0.0003581097,0.003022866,0.00007517362,0.00003081467,0.00004899975,0.000464075,0.00003284778,0.003058864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408292,"threshold_uncertainty_score":0.004711151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963154682161669,"score_gpt":0.2168887973025634,"score_spread":0.1872572504809467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}