{"id":"W2040693145","doi":"10.1016/j.jdermsci.2008.04.003","title":"Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita","year":2008,"lang":"en","type":"review","venue":"Journal of Dermatological Science","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal University Hospital; University of Saskatchewan","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"RNA interference; Epidermolysis bullosa simplex; Small interfering RNA; Mutant; Phenotype; Allele; Genetics; Medicine; Human genome; Biology; Bioinformatics; Computational biology; Cancer research; RNA; Genome; Keratin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004716424,0.001056761,0.001225191,0.0009361802,0.0002321999,0.000501933,0.0007584214,0.001008069,0.002779274],"category_scores_gemma":[0.0002824046,0.0002530531,0.0004156076,0.0005225968,0.0003723204,0.0006293029,0.0004515804,0.001476951,0.001767183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003878937,"about_ca_system_score_gemma":0.0003714996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003464629,"about_ca_topic_score_gemma":0.0009767537,"domain_scores_codex":[0.9998865,0.000017527,0.00001473165,0.00001690607,0.00004661852,0.0000176768],"domain_scores_gemma":[0.9998862,0.00005763439,0.00002046082,0.000006166852,0.00001903416,0.00001050945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001646042,0.0001122246,0.0001146935,0.004938679,0.00007260824,0.0007544297,0.00003535165,0.0004425536,0.04070294,0.003552452,0.02165806,0.9274514],"study_design_scores_gemma":[0.0001494635,0.0003539055,0.001118909,0.0009400982,0.0002289123,0.004802465,0.00004190287,0.00037631,0.03140499,0.00214627,0.9584021,0.00003474619],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002205856,0.9871755,0.004479253,0.0004847961,0.0007453022,0.0000460261,0.00007721002,0.0001255432,0.004660554],"genre_scores_gemma":[0.0123534,0.9723454,0.004461573,0.0008408196,0.0003350754,0.0001600899,0.0002772411,0.00002492963,0.009201512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002779274,"threshold_uncertainty_score":0.009297609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06107179302593758,"score_gpt":0.3764823678333951,"score_spread":0.3154105748074575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}