{"id":"W2040698429","doi":"10.1021/bi801532g","title":"Residues Responsible for the Asymmetric Function of the Nucleotide Binding Domains of Multidrug Resistance Protein 1","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ATP-binding cassette transporter; ATP hydrolysis; Nucleotide; Biochemistry; Chemistry; Mutant; Walker motifs; Transporter; Cyclic nucleotide-binding domain; Amino acid; Biology; Enzyme; ATPase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003316672,0.0001183426,0.0002185326,0.00005587768,0.000199971,0.000002913074,0.0001853313,0.00009992387,0.00001131095],"category_scores_gemma":[0.0002730237,0.00006893113,0.0002006462,0.0005031592,0.0002255696,0.00002267363,0.00001982368,0.0001257733,9.86699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000415507,"about_ca_system_score_gemma":0.0002347057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001308134,"about_ca_topic_score_gemma":0.00001727464,"domain_scores_codex":[0.9989635,0.0000193984,0.0003150616,0.0001975579,0.0003288858,0.0001755485],"domain_scores_gemma":[0.9989381,0.0001361617,0.0002200346,0.0005184357,0.0001455512,0.00004172763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001335357,0.00008240188,0.001936178,0.0005189989,0.00005739368,0.000003231357,0.00009380496,0.000001719948,0.9943307,0.0003018002,0.001215385,0.0001230194],"study_design_scores_gemma":[0.0009435004,0.00004461767,0.01530434,0.0003698013,0.00009957506,0.000004007944,0.0002614305,0.00001042926,0.9809408,0.0001300589,0.001816528,0.0000748723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948867,0.001069178,0.0005548596,0.0006564265,0.000108864,0.0007021126,0.00005109171,0.00002491815,0.001945842],"genre_scores_gemma":[0.9789272,0.00005937755,0.002607909,0.00002721359,0.0000875082,0.00004970769,0.00001057169,0.00002023768,0.01821029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01626445,"threshold_uncertainty_score":0.281093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509418339340547,"score_gpt":0.2330640858139188,"score_spread":0.2179699024205133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}