{"id":"W2040718125","doi":"10.1097/01.fpc.0000230413.97596.fa","title":"Multilocus genetic interactions and response to efavirenz-containing regimens: an Adult AIDS Clinical Trials Group study","year":2006,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Center for Research Resources; ACT Government; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases","keywords":"Efavirenz; CYP2B6; Pharmacogenetics; Pharmacology; Nelfinavir; Single-nucleotide polymorphism; Biology; Medicine; Internal medicine; Genotype; Oncology; CYP3A4; Viral load; Virology; Genetics; Gene; Cytochrome P450; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006216609,0.0008688862,0.001121643,0.0002986011,0.0004566699,0.0006846916,0.0004266755,0.001066756,0.002018979],"category_scores_gemma":[0.008349262,0.0003824609,0.0009940488,0.0004791887,0.0003593219,0.0005426304,0.0003160507,0.001033244,0.0002834458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430006,"about_ca_system_score_gemma":0.0004381796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000620781,"about_ca_topic_score_gemma":0.0007942618,"domain_scores_codex":[0.9965008,0.002811091,0.0001528874,0.0002691683,0.0001638158,0.0001022132],"domain_scores_gemma":[0.9934937,0.003167348,0.001738955,0.0006032932,0.0003207073,0.0006759964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3740061,0.005668119,0.5721242,0.0003699814,0.01150375,0.0003506435,0.0003765152,0.00243136,0.00205415,0.0002518549,0.001752994,0.02911036],"study_design_scores_gemma":[0.1285358,0.06981363,0.7745174,0.0001397637,0.008068077,0.0008527253,0.0002092409,0.01381178,0.0006760161,0.000781106,0.00250061,0.00009393742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998041,0.0007024053,0.0002617144,0.0001848959,0.00001891278,0.0001323683,0.0003169082,0.000008002281,0.0003338129],"genre_scores_gemma":[0.9982803,0.0001891444,0.0005155599,0.0001228135,0.00005836198,0.0001569147,0.0004244224,0.000002720291,0.0002497404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006216609,"threshold_uncertainty_score":0.03287697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08553449737478164,"score_gpt":0.4370506260796645,"score_spread":0.3515161287048829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}