{"id":"W2040735698","doi":"10.1038/onc.2008.499","title":"The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; National Cancer Institute; National Institutes of Health; Institut National Du Cancer","keywords":"Biology; DNA damage; Cancer research; Histone; Cancer; Carcinogenesis; DNA repair; Chromatin; Oncogene; Histone acetyltransferase; Colorectal cancer; Apoptosis; Cell growth; Chromatin remodeling; Cell cycle; DNA; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003538394,0.0001514222,0.0001130061,0.000008381661,0.0002810287,0.00006119961,0.0001777116,0.0001652925,0.00003020362],"category_scores_gemma":[0.0002283212,0.0001204111,0.0001050386,0.00005003657,0.0000554515,0.000009725253,0.00003919067,0.00005520092,0.000008059493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004994041,"about_ca_system_score_gemma":0.0002259787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007239781,"about_ca_topic_score_gemma":0.00006861646,"domain_scores_codex":[0.9989136,0.0001180729,0.0001946591,0.0003370094,0.0001448009,0.0002918351],"domain_scores_gemma":[0.9993531,0.00007000339,0.00005376427,0.0003005295,0.0001591601,0.00006341281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001209909,0.00007598586,0.00000818491,0.00000610878,0.0000133544,0.000002438451,0.00016266,0.000006952574,0.9896845,0.0009452442,0.00608826,0.001796439],"study_design_scores_gemma":[0.0005133367,0.001169045,0.00008904642,0.000005157982,0.00002276449,0.0000057151,0.0001031791,0.0004233437,0.9538125,0.0008562526,0.0428414,0.0001582003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868923,0.001012956,0.007247472,0.002367818,0.0002518732,0.0006196793,0.0001355338,0.00002988674,0.001442509],"genre_scores_gemma":[0.9932375,0.0001784179,0.00281752,0.001743745,0.0004254561,0.0002146722,0.00007121409,0.00002403803,0.001287442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03675314,"threshold_uncertainty_score":0.4910223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587874566362244,"score_gpt":0.2952415877987933,"score_spread":0.2793628421351708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}