{"id":"W2040751957","doi":"10.1038/sj.bjp.0703252","title":"Enhanced relaxation of porcine coronary arteries after acute exposure to a physiological level of 17β‐estradiol involves non‐genomic mechanisms and the cyclic AMP cascade","year":2000,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"University of Hong Kong","keywords":"Sodium nitroprusside; Activator (genetics); Bradykinin; Chemistry; Endocrinology; Cyclic nucleotide; Phosphodiesterase inhibitor; Protein kinase A; Internal medicine; Phosphodiesterase; Cycloheximide; Vasodilation; Biophysics; Kinase; Biochemistry; Biology; Nitric oxide; Medicine; Receptor; Enzyme; Nucleotide; Protein biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229075,0.0001188112,0.0003427144,0.00003768449,0.00004508248,0.000007096361,0.0001522499,0.0001731854,0.00009077659],"category_scores_gemma":[0.00001798923,0.00009468937,0.0001290488,0.00005926284,0.0002489436,0.000009655707,0.00004599062,0.0002040686,0.000001716721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009000474,"about_ca_system_score_gemma":0.00004877803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001313133,"about_ca_topic_score_gemma":0.000005911415,"domain_scores_codex":[0.9989832,0.0001877846,0.0004217437,0.0001536481,0.00008991663,0.0001636857],"domain_scores_gemma":[0.9994757,0.00002850875,0.0002710746,0.00006451782,0.00008530173,0.0000748696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002872816,0.00009513363,0.00003759768,0.00001698951,0.000311564,0.00009366335,0.00017796,0.0001438744,0.9892882,0.00000608603,0.0007938666,0.006162226],"study_design_scores_gemma":[0.004195224,0.002433329,0.04622297,0.00006602227,0.0002519734,0.003230509,0.00005274799,0.00001695397,0.943108,0.0001302521,0.0001582949,0.0001337398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954336,0.00347299,0.0004819766,0.0001676097,0.0001383012,0.000236828,0.00004031037,0.000002051693,0.00002635519],"genre_scores_gemma":[0.9928967,0.00570041,0.000712031,0.0003564821,0.0001450623,0.00001675813,0.00001165171,0.00001225795,0.0001486637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04618537,"threshold_uncertainty_score":0.3861321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128989342507656,"score_gpt":0.2564193728542621,"score_spread":0.2451294794291855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}