{"id":"W2040792744","doi":"10.1074/jbc.m111.334565","title":"Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Huntingtin; Chemistry; Dithiol; Peroxiredoxin; Reactive oxygen species; Biochemistry; Antioxidant; Toxicity; Mutant; Molecular biology; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008438904,0.0002849303,0.0002389954,0.0001703374,0.0001197012,0.000164319,0.0002089624,0.0002210628,0.0004780896],"category_scores_gemma":[0.00008475187,0.00008290124,0.0001324192,0.0001332979,0.0001299099,0.0001460673,0.00009434927,0.0003364232,0.00007855631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193869,"about_ca_system_score_gemma":0.0001462174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222929,"about_ca_topic_score_gemma":0.001074958,"domain_scores_codex":[0.9999406,0.000008526211,0.000007480595,0.00001400115,0.00001589184,0.00001347043],"domain_scores_gemma":[0.9999403,0.000009194935,0.00001799176,0.00000870188,0.00001229257,0.00001151749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000535708,0.00002525763,0.00006940337,0.00002293811,0.000005076581,0.00002081557,0.000007126607,0.00002224909,0.9990351,0.00002130475,0.00001337521,0.0007037345],"study_design_scores_gemma":[0.000009627588,0.0002800193,0.001549117,0.000001793065,0.00001464074,0.00007575747,0.00000947687,0.0001629463,0.9969926,0.00001334366,0.0008888677,0.000001778131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963275,0.001821707,0.001190851,0.00005423911,0.00001606331,0.00003374859,0.0001099761,0.00005395006,0.000392031],"genre_scores_gemma":[0.9946973,0.001409148,0.002157242,0.00003891339,0.00001347191,0.00003360484,0.0003579025,0.0000100515,0.001282303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004780896,"threshold_uncertainty_score":0.001599371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04788242937758584,"score_gpt":0.2768987780340885,"score_spread":0.2290163486565027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}