{"id":"W2040807402","doi":"10.1038/onc.2012.8","title":"Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Demethylase; Transcription factor; Epigenetics; Jurkat cells; DNA methylation; Cell biology; Cancer research; Genetics; Gene expression; Gene; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002823379,0.0001453411,0.0001562628,0.00008226012,0.00006540016,0.00002331474,0.00004186421,0.0001739807,0.00001156587],"category_scores_gemma":[0.00004011371,0.0001474992,0.00003413606,0.00009113086,0.00004535277,0.00001629329,0.00007883961,0.00005992395,0.000004699387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000038787,"about_ca_system_score_gemma":0.00001902792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007258446,"about_ca_topic_score_gemma":0.0001247995,"domain_scores_codex":[0.9991602,0.00006464194,0.0002110641,0.0002612506,0.00008747749,0.0002153872],"domain_scores_gemma":[0.9995902,0.00001975958,0.00008856264,0.0001742536,0.00003080556,0.00009642934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000457343,0.00002929502,0.0646818,0.00002640415,0.00002827381,4.406754e-7,0.00006110471,0.00001719266,0.8957155,0.00001260714,0.00001373755,0.03936787],"study_design_scores_gemma":[0.0005464926,0.0002308579,0.1993384,0.00002798089,0.00004790561,0.000008861705,0.000130507,0.000134823,0.7916527,0.0002519345,0.007380978,0.0002485017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989563,0.008770477,0.00102893,0.00006904909,0.0001211133,0.0001675712,0.000009767623,0.000009477601,0.0002605714],"genre_scores_gemma":[0.9977174,0.000733284,0.000974218,0.00002563666,0.0001732335,0.00002243198,0.0001210138,0.00002347582,0.0002093065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1346566,"threshold_uncertainty_score":0.6014842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068329492223451,"score_gpt":0.262861884560792,"score_spread":0.2521785896385575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}