{"id":"W2040807402","doi":"10.1038/onc.2012.8","title":"Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Demethylase; Transcription factor; Epigenetics; Jurkat cells; DNA methylation; Cell biology; Cancer research; Genetics; Gene expression; Gene; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137308,0.0002274481,0.0002061326,0.0003388808,0.0005057108,0.0007454296,0.0005087015,0.0003029148,0.002129068],"category_scores_gemma":[0.0002139628,0.0002207631,0.0002259485,0.0001718094,0.0003705312,0.0006982304,0.0006304134,0.0005286406,0.0005035719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008501063,"about_ca_system_score_gemma":0.000308656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006295606,"about_ca_topic_score_gemma":0.001175898,"domain_scores_codex":[0.9998236,0.00002128126,0.00001048509,0.00004081365,0.00004314704,0.00006066347],"domain_scores_gemma":[0.9998776,0.00001398167,0.000032263,0.00001025122,0.00001599325,0.00004995786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002372002,0.00002321603,0.001520996,0.00003399215,0.00001202226,0.0001529651,0.00003950115,0.0001743763,0.9936633,0.001446891,0.0001607537,0.002534851],"study_design_scores_gemma":[0.00002741595,0.00007911099,0.02051846,0.000006364289,0.00003070921,0.0004560401,0.0001929554,0.004728463,0.9689648,0.0007613142,0.00421738,0.00001706619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902744,0.002799389,0.003879768,0.0002976436,0.00004195048,0.000009330847,0.0001730513,0.0001215629,0.002402938],"genre_scores_gemma":[0.9975051,0.0002276714,0.0004661799,0.0000245038,0.000006197663,0.000005070576,0.0001021973,0.00001029116,0.001652788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129068,"threshold_uncertainty_score":0.007122457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068329492223451,"score_gpt":0.262861884560792,"score_spread":0.2521785896385575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}