{"id":"W2040822794","doi":"10.1615/critrevimmunol.v29.i4.50","title":"Tyrosine Phosphorylation in Immune Cells: Direct and Indirect Effects on Toll-Like Receptor-Induced Proinflammatory Cytokine Production","year":2009,"lang":"en","type":"review","venue":"Critical Reviews in Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protein tyrosine phosphatase; Tyrosine phosphorylation; Receptor tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Cell biology; JAK-STAT signaling pathway; Phosphorylation; ROR1; Signal transduction; Tyrosine kinase; Biology; Proinflammatory cytokine; SH2 domain; Platelet-derived growth factor receptor; Cancer research; Chemistry; Biochemistry; Receptor; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003858787,0.0008703678,0.00119742,0.001051045,0.0002166227,0.0007435328,0.0007197779,0.001031537,0.002151608],"category_scores_gemma":[0.0002863327,0.0002307409,0.0003206154,0.001262555,0.0004544524,0.001078421,0.0005147487,0.001242035,0.002704281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005564871,"about_ca_system_score_gemma":0.0004250164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003906815,"about_ca_topic_score_gemma":0.0005723744,"domain_scores_codex":[0.9998461,0.00002443069,0.00001950774,0.00002723998,0.00006253505,0.00002009323],"domain_scores_gemma":[0.9998775,0.00004392746,0.00002140057,0.000004329749,0.00003340015,0.00001941029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001545209,0.00007189919,0.0002363936,0.01426702,0.00007200734,0.0005477301,0.00007537537,0.0003532798,0.0206541,0.004323881,0.0257395,0.9335042],"study_design_scores_gemma":[0.00003077089,0.0001837651,0.001649591,0.001865976,0.0000900306,0.003280496,0.00006767546,0.00009377518,0.005164452,0.002810294,0.9847361,0.00002704351],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002156946,0.9985683,0.0001261803,0.0001130335,0.0002133253,0.00000245697,0.000007716266,0.000006357435,0.0007468313],"genre_scores_gemma":[0.001185248,0.9976189,0.0001214217,0.0001245159,0.0002188291,0.000004332114,0.00001591889,0.000001199303,0.0007097516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002151608,"threshold_uncertainty_score":0.007197857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02618132684902745,"score_gpt":0.3050651205419457,"score_spread":0.2788837936929183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}