{"id":"W2040826145","doi":"10.1210/en.2003-0677","title":"The Constitutively Active N111G-AT1 Receptor for Angiotensin II Maintains a High Affinity Conformation Despite Being Uncoupled from Its Cognate G Protein Gq/11α","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Angiotensin II receptor type 1; Receptor; Agonist; Angiotensin II; Chemistry; Mutant; Enzyme-linked receptor; G protein-coupled receptor; Biochemistry; Biophysics; Internal medicine; Molecular biology; Biology; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221519,0.0002513071,0.0002575503,0.0000482816,0.0006948273,0.00003359207,0.000210035,0.0002066723,0.0001060987],"category_scores_gemma":[0.0006329992,0.0002065711,0.0001331158,0.00008135305,0.000168743,0.00001538624,0.0001055521,0.0001874871,0.00002305895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005244914,"about_ca_system_score_gemma":0.0001864653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005931009,"about_ca_topic_score_gemma":0.00007510397,"domain_scores_codex":[0.9983645,0.0001849124,0.0003352039,0.0004108615,0.0001145001,0.0005899992],"domain_scores_gemma":[0.999037,0.0001080552,0.0002196218,0.0002653021,0.0002845855,0.00008538621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004247749,0.00004100065,0.00001890592,0.000006555498,0.0001883195,0.000004889291,0.0001591772,0.00005028535,0.9313989,0.0642909,0.0004274893,0.002988795],"study_design_scores_gemma":[0.001426995,0.0004601942,0.00005934341,0.00001696311,0.00003080928,0.00001563282,0.000319172,0.0001120221,0.8780323,0.003333783,0.115952,0.0002408297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761604,0.0004049406,0.0202547,0.0004236803,0.0006373778,0.001154465,0.000206119,0.00003838817,0.0007199472],"genre_scores_gemma":[0.9936392,0.0001787284,0.004685867,0.0002648332,0.0001822568,0.0002282655,0.0003154007,0.00002678771,0.0004786894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1155245,"threshold_uncertainty_score":0.8423725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092953101265956,"score_gpt":0.231820903875845,"score_spread":0.2208913728631854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}