{"id":"W2040826145","doi":"10.1210/en.2003-0677","title":"The Constitutively Active N111G-AT1 Receptor for Angiotensin II Maintains a High Affinity Conformation Despite Being Uncoupled from Its Cognate G Protein Gq/11α","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Angiotensin II receptor type 1; Receptor; Agonist; Angiotensin II; Chemistry; Mutant; Enzyme-linked receptor; G protein-coupled receptor; Biochemistry; Biophysics; Internal medicine; Molecular biology; Biology; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633063,0.0004580484,0.0003652913,0.0001175633,0.0001397722,0.0003822351,0.0003432028,0.0003122111,0.0006124519],"category_scores_gemma":[0.0001850272,0.0001523305,0.0002851232,0.0001898307,0.0004697971,0.0001825535,0.0002027456,0.0007311444,0.0004053297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477993,"about_ca_system_score_gemma":0.0002658544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008501265,"about_ca_topic_score_gemma":0.00109673,"domain_scores_codex":[0.9997991,0.00003764308,0.0000233426,0.00004583983,0.00005238719,0.00004162602],"domain_scores_gemma":[0.9998386,0.00003836873,0.00004456623,0.0000269081,0.000013743,0.00003786391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007137134,0.00001344898,0.0001328255,0.00001082987,0.000003839706,0.00003842481,0.000007356787,0.0000399284,0.9994318,0.00005144603,0.000007272721,0.0001914451],"study_design_scores_gemma":[0.00003540311,0.000296426,0.004395358,0.000005390302,0.0000247195,0.0007730995,0.00004319022,0.001421331,0.9914932,0.00005723007,0.001443111,0.0000114463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987354,0.0001355062,0.0007081738,0.0000325365,0.0000089519,0.000007655623,0.0001043174,0.00001154888,0.0002559804],"genre_scores_gemma":[0.9962378,0.0002122663,0.001800102,0.00004024484,0.000007057617,0.00002062095,0.0006034081,0.00002379333,0.001054802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008501265,"threshold_uncertainty_score":0.003974557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092953101265956,"score_gpt":0.231820903875845,"score_spread":0.2208913728631854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}