{"id":"W2040837189","doi":"10.1089/hum.2004.15.1157","title":"The Innate Immune Response to Adenovirus Vectors","year":2004,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":407,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Innate immune system; Biology; Immune system; Acquired immune system; Transduction (biophysics); Adenoviridae; Immunology; Viral vector; Genetic enhancement; CCL18; Effector; Pattern recognition receptor; Immunity; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003694357,0.0007495442,0.0009589402,0.001311074,0.0002434732,0.000901418,0.0006737364,0.0009206925,0.003015493],"category_scores_gemma":[0.0003517096,0.000254524,0.0002992461,0.001087357,0.000524167,0.000777705,0.0004001313,0.001310435,0.003884427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007223227,"about_ca_system_score_gemma":0.0005759444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006615862,"about_ca_topic_score_gemma":0.0007501571,"domain_scores_codex":[0.9998172,0.00002944962,0.00001886135,0.00003344824,0.00008483775,0.00001629547],"domain_scores_gemma":[0.9998505,0.00006405447,0.00002036049,0.000007629502,0.00004346141,0.00001392964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008198356,0.0000734395,0.0002287506,0.008103454,0.00003898327,0.0004100218,0.0001049172,0.000313574,0.01872307,0.006439735,0.02132029,0.9441618],"study_design_scores_gemma":[0.00001122821,0.00007344119,0.0005540881,0.0006642552,0.00002105978,0.001453372,0.00004056094,0.00004501426,0.003865043,0.001318462,0.991944,0.00000950829],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004572066,0.9931763,0.0006773334,0.0002503587,0.0003551992,0.00001199784,0.00002059995,0.00002390808,0.005027079],"genre_scores_gemma":[0.00179634,0.9936252,0.0005271159,0.0002494181,0.0001448836,0.0000182566,0.00004553682,0.000002978211,0.003590251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003015493,"threshold_uncertainty_score":0.01008779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05521089473172554,"score_gpt":0.3795192086263247,"score_spread":0.3243083138945992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}