{"id":"W2040837189","doi":"10.1089/hum.2004.15.1157","title":"The Innate Immune Response to Adenovirus Vectors","year":2004,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":407,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Innate immune system; Biology; Immune system; Acquired immune system; Transduction (biophysics); Adenoviridae; Immunology; Viral vector; Genetic enhancement; CCL18; Effector; Pattern recognition receptor; Immunity; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00185469,0.0007554606,0.000931857,0.0002439046,0.0006985858,0.0001684452,0.001834629,0.0005088868,0.0001062364],"category_scores_gemma":[0.00008024598,0.0005340686,0.0007453064,0.0004496165,0.0002372398,0.000002445937,0.0003376247,0.0005055359,0.0003346692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824449,"about_ca_system_score_gemma":0.001033711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002427739,"about_ca_topic_score_gemma":0.00006105381,"domain_scores_codex":[0.9957353,0.00124156,0.0007416654,0.000925655,0.0004859995,0.0008698219],"domain_scores_gemma":[0.9970105,0.00007761361,0.0002754191,0.002242921,0.0001503089,0.000243199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006941912,0.000124347,4.164094e-7,0.0003282414,0.0008430758,0.00003081738,0.0001139584,0.00001942457,0.3287636,0.00001822273,0.001130849,0.6616851],"study_design_scores_gemma":[0.0007803479,0.0049246,0.00001292563,0.0005126151,0.00003972476,0.00003609218,0.000007313367,5.087838e-8,0.0464967,0.00004508846,0.946534,0.0006105435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04143015,0.9563653,0.00001066608,0.00009509987,0.0002580483,0.001663112,0.00005648866,0.0000394227,0.00008166344],"genre_scores_gemma":[0.0006017039,0.9924164,0.00003731778,0.0002360312,0.0007222169,0.0005488301,0.0002679223,0.0002861938,0.004883428],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9454032,"threshold_uncertainty_score":0.9997111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05521089473172554,"score_gpt":0.3795192086263247,"score_spread":0.3243083138945992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}