{"id":"W2040852160","doi":"10.1111/bjh.13016","title":"A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome","year":2014,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Merck","keywords":"Decitabine; Vorinostat; Medicine; Tolerability; Myelodysplastic syndromes; Internal medicine; Oncology; Refractory (planetary science); Myeloid leukemia; Pharmacology; Adverse effect; Histone deacetylase; Bone marrow; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008408233,0.0001386565,0.0007164507,0.0002373814,0.00002677952,0.00001435606,0.0002339098,0.0002028095,0.00001331267],"category_scores_gemma":[0.0008963437,0.0001188559,0.00007281143,0.0002348503,0.0002742484,0.0000180365,0.00005701875,0.0003932016,0.000001622836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003562332,"about_ca_system_score_gemma":0.0003529823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000324063,"about_ca_topic_score_gemma":0.0005627611,"domain_scores_codex":[0.9976286,0.0004507368,0.001031858,0.0002534806,0.0003453397,0.0002899767],"domain_scores_gemma":[0.9986743,0.0001583986,0.0005105371,0.0001756184,0.0003616818,0.0001194531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6813918,0.02571377,0.1662969,0.0003896827,0.0009426746,0.06229623,0.0002045607,0.0001991212,0.004347736,0.0001291077,0.002299127,0.05578936],"study_design_scores_gemma":[0.6966017,0.1223349,0.09234643,0.001395846,0.0001530423,0.0768965,0.00006446612,0.0001498124,0.008419693,0.00007595091,0.000958537,0.0006031405],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986221,0.00007620069,0.0006734573,0.00004785532,0.0001737426,0.0003598714,0.00001716233,0.00000206479,0.00002753452],"genre_scores_gemma":[0.9987947,0.00009681451,0.0009295144,0.0000232213,0.00004481474,0.00001112574,0.00004449302,0.00002358839,0.00003174473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0966211,"threshold_uncertainty_score":0.4846805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235279551165392,"score_gpt":0.3094381602760078,"score_spread":0.2970853647643539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}