{"id":"W2040853326","doi":"10.1128/aac.00846-12","title":"Reduced Expression of the <i>rplU-rpmA</i> Ribosomal Protein Operon in <i>mexXY</i> -Expressing Pan-Aminoglycoside-Resistant Mutants of Pseudomonas aeruginosa","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; Cystic Fibrosis Canada","keywords":"Operon; Mutant; Pseudomonas aeruginosa; Biology; Efflux; Aminoglycoside; Ribosomal protein; Microbiology; Repressor; Mutation; Gene; Genetics; Gene expression; Ribosome; RNA; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122807,0.0005451355,0.0003874787,0.0001932338,0.0001341248,0.0004207196,0.0003185375,0.0003273664,0.0007061737],"category_scores_gemma":[0.00021105,0.0002472392,0.0003058276,0.0001690414,0.0002500186,0.0001953146,0.0003452083,0.0006565248,0.0005102942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002849898,"about_ca_system_score_gemma":0.0002525075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001475048,"about_ca_topic_score_gemma":0.001356674,"domain_scores_codex":[0.9997072,0.0000413638,0.00004097018,0.00004512362,0.0001136876,0.00005164443],"domain_scores_gemma":[0.9997545,0.00002997704,0.00009317846,0.0000331316,0.00003185797,0.00005736224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001670469,0.000007555377,0.00006596346,0.000007122912,0.000001463579,0.00002348382,0.000007165276,0.00001229246,0.9997025,0.00001164331,0.000008238896,0.0001358251],"study_design_scores_gemma":[0.000007006793,0.0001628523,0.006694007,0.000003757325,0.00001272106,0.0005318874,0.0000463341,0.0008308127,0.9910406,0.00001867124,0.0006433301,0.000007997814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968908,0.0002567755,0.001769092,0.00006936161,0.00001415949,0.00001836393,0.0003620732,0.00008534676,0.0005340026],"genre_scores_gemma":[0.9958895,0.0001609877,0.001766827,0.00003832453,0.000006219442,0.00002353328,0.0007392081,0.00005532803,0.001320211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475048,"threshold_uncertainty_score":0.002932906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077160323711907,"score_gpt":0.2343512692899015,"score_spread":0.2235796660527824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}