{"id":"W2040866987","doi":"10.1006/cimm.2000.1757","title":"The Affinity/Avidity and Length of Exposure to the Deleting Ligand Determine Dependence on CD28 for the Efficient Deletion of Self-Specific CD4+CD8+ Thymocytes","year":2001,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Arthritis Society","keywords":"Avidity; T-cell receptor; Biology; Thymocyte; CD28; CD8; Molecular biology; Point mutation; CD3; Ligand (biochemistry); Negative selection; T cell; Antigen; Receptor; Mutation; Immunology; Genetics; Gene; Immune system; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001182345,0.0003156125,0.000465055,0.0001064868,0.001017273,0.00002416995,0.0008993221,0.0003903402,0.00004566212],"category_scores_gemma":[0.0002764217,0.0001719909,0.0001779058,0.0002399995,0.0009452009,0.00003181089,0.0003201004,0.0005449372,0.00007700951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003960266,"about_ca_system_score_gemma":0.0000602177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006549522,"about_ca_topic_score_gemma":0.00007265158,"domain_scores_codex":[0.9976345,0.0005356469,0.0006676296,0.0004528927,0.00007842323,0.0006308955],"domain_scores_gemma":[0.995484,0.002961853,0.0004068138,0.0009257523,0.0002014839,0.00002010641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009500374,0.0002307446,0.0004673421,0.00001752529,0.0002953986,0.000004176333,0.0009834408,0.0001770497,0.9804931,0.002151264,0.0002546278,0.01397535],"study_design_scores_gemma":[0.00158236,0.00161154,0.002618702,0.0000402544,0.0001136382,0.0001638075,0.001233356,0.00006168223,0.8816645,0.0001216286,0.1105741,0.0002144062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504457,0.04441341,0.001296016,0.001563836,0.001174946,0.0009170843,0.00001955524,0.00004708797,0.0001223689],"genre_scores_gemma":[0.9952525,0.003895344,0.00008288819,0.0001045818,0.00006571626,0.0001111302,0.00002358419,0.00002781112,0.0004363763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1103195,"threshold_uncertainty_score":0.7824144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567780903793144,"score_gpt":0.2144174805548526,"score_spread":0.1987396715169211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}