{"id":"W2040866987","doi":"10.1006/cimm.2000.1757","title":"The Affinity/Avidity and Length of Exposure to the Deleting Ligand Determine Dependence on CD28 for the Efficient Deletion of Self-Specific CD4+CD8+ Thymocytes","year":2001,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Arthritis Society","keywords":"Avidity; T-cell receptor; Biology; Thymocyte; CD28; CD8; Molecular biology; Point mutation; CD3; Ligand (biochemistry); Negative selection; T cell; Antigen; Receptor; Mutation; Immunology; Genetics; Gene; Immune system; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005421865,0.0003950214,0.0003843119,0.0003595754,0.0002791849,0.0008879111,0.0005654309,0.0006274625,0.00477052],"category_scores_gemma":[0.0008306211,0.0004519668,0.000384869,0.0001408718,0.0003258901,0.0007069798,0.0006321848,0.001986885,0.001781018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006511137,"about_ca_system_score_gemma":0.0004486743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004412184,"about_ca_topic_score_gemma":0.0014111,"domain_scores_codex":[0.9992825,0.0001491836,0.00006531535,0.00008545709,0.0001523023,0.0002651814],"domain_scores_gemma":[0.9987066,0.0005665613,0.0001441721,0.0001433066,0.0001650977,0.0002741911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003950683,0.00001701326,0.0002617454,0.00001148791,0.000003058393,0.00001649034,0.00001007649,0.00005375133,0.9988262,0.0001018258,0.00001373992,0.0006450613],"study_design_scores_gemma":[0.0000216335,0.0002817871,0.006669132,0.00001538616,0.00003017602,0.0006745184,0.00006727678,0.001677418,0.9885616,0.0002487911,0.001741878,0.00001045148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897405,0.001623061,0.005220006,0.0001928448,0.00004809929,0.00002747361,0.0001420899,0.00006184381,0.002944043],"genre_scores_gemma":[0.9938631,0.0006208854,0.002954675,0.0001379706,0.00003502131,0.00002470761,0.0003115809,0.00007269474,0.001979317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00477052,"threshold_uncertainty_score":0.01595896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567780903793144,"score_gpt":0.2144174805548526,"score_spread":0.1987396715169211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}