{"id":"W2040871017","doi":"10.1016/j.molcel.2006.07.035","title":"DNA Degradation at Unprotected Telomeres in Yeast Is Regulated by the CDK1 (Cdc28/Clb) Cell-Cycle Kinase","year":2006,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute","keywords":"Genome instability; Telomere; Biology; Cyclin-dependent kinase 1; Cell biology; Cell cycle; DNA re-replication; Saccharomyces cerevisiae; DNA repair; DNA damage; DNA; Genetics; Cell; Eukaryotic DNA replication; Yeast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001726329,0.0003139007,0.0003226032,0.0001696562,0.0001517968,0.00004097208,0.000219157,0.0001960942,0.000319678],"category_scores_gemma":[0.00003175997,0.0002515089,0.0001339212,0.0007428766,0.0001335615,0.00006641645,0.00008029681,0.0003046689,0.0001914379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776407,"about_ca_system_score_gemma":0.00007416913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001974474,"about_ca_topic_score_gemma":0.0001965507,"domain_scores_codex":[0.9978635,0.0001464738,0.0004426766,0.0005350637,0.0005014818,0.0005108584],"domain_scores_gemma":[0.9988852,0.00003364545,0.0001507157,0.0007035243,0.00009271409,0.0001342445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001413767,0.0003414353,0.002249825,0.00008728324,0.00001332152,0.0002556176,0.000210575,0.00005256697,0.9821684,0.00001680806,0.01188797,0.002574817],"study_design_scores_gemma":[0.002075945,0.0001039118,0.01390437,0.00006234772,0.00006382474,0.0000261338,0.0001180109,0.000842159,0.9609545,0.00008931992,0.02144804,0.0003114423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988875,0.002024308,0.0002824159,0.001164651,0.00008885084,0.000779591,0.00003539101,0.0001159242,0.006633845],"genre_scores_gemma":[0.9879824,0.00005002657,0.0003005562,0.0008390318,0.00005524155,0.00003985872,0.0003037402,0.00006544553,0.01036372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02121391,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005081358839324048,"score_gpt":0.2010377006117716,"score_spread":0.1959563417724476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}