{"id":"W2040873123","doi":"10.1016/j.bbrc.2014.09.030","title":"Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages","year":2014,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province; National Natural Science Foundation of China","keywords":"THP1 cell line; MAPK/ERK pathway; Foam cell; NF-κB; Chemistry; Cell biology; Urotensin-II; Molecular biology; Signal transduction; Macrophage; Biology; Biochemistry; Cell culture; Receptor; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033822,0.0003241823,0.0003800622,0.0002127551,0.0001907562,0.0003922967,0.0001319185,0.0002505388,0.002053708],"category_scores_gemma":[0.0001945547,0.0002453779,0.000334899,0.0001814036,0.0004209017,0.0002461033,0.0001997168,0.0008521257,0.0003328101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161324,"about_ca_system_score_gemma":0.0002414083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007108441,"about_ca_topic_score_gemma":0.0007733399,"domain_scores_codex":[0.9997773,0.00003644413,0.00002477507,0.00004006917,0.00003648955,0.00008494495],"domain_scores_gemma":[0.9998139,0.00002781638,0.00004623958,0.00002342785,0.0000209337,0.00006775033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009530899,0.00008247887,0.0003028656,0.00007558985,0.000009152868,0.00007094112,0.00003599468,0.00003602308,0.9975361,0.00005145581,0.00006830766,0.000778045],"study_design_scores_gemma":[0.0001443213,0.001336135,0.01818319,0.00001982293,0.00006250232,0.0002108967,0.0002567828,0.001003815,0.9767611,0.0001321439,0.001874591,0.00001481082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966015,0.001002088,0.001149731,0.0001707862,0.00008230028,0.0000181269,0.0002563731,0.00004566778,0.0006734771],"genre_scores_gemma":[0.9954972,0.0008448062,0.0009136209,0.00012389,0.00003640181,0.00004026113,0.0003489653,0.000012871,0.002182014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002053708,"threshold_uncertainty_score":0.006870329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.062035747828703,"score_gpt":0.3557023957607005,"score_spread":0.2936666479319975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}