{"id":"W2040914087","doi":"10.1038/sj.onc.1207791","title":"Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Alberta Heritage Foundation for Medical Research; Canada Research Chairs; National Institutes of Health; American Cancer Society","keywords":"Biology; Methyltransferase; DNA repair; Mutation; MSH6; Genetics; Mutant; Lac repressor; DNA mismatch repair; O-6-methylguanine-DNA methyltransferase; DNA damage; Mutagenesis; Transgene; Mutation frequency; DNA; Molecular biology; Gene; Plasmid; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000333166,0.001107496,0.0003863775,0.001042836,0.0003912318,0.0005844989,0.0006688703,0.001039094,0.004087404],"category_scores_gemma":[0.000285592,0.0004374184,0.0005208051,0.0002663598,0.0006187671,0.0006269556,0.0005082745,0.001835306,0.001435767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003888252,"about_ca_system_score_gemma":0.000322474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004929421,"about_ca_topic_score_gemma":0.001234078,"domain_scores_codex":[0.9996806,0.00003508399,0.00004091084,0.00008822325,0.0001028556,0.0000523087],"domain_scores_gemma":[0.9990207,0.0001820267,0.0003472035,0.0001425131,0.00005732101,0.0002502877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008691105,0.00001412487,0.0001732593,0.00001519315,0.000004182701,0.0000602923,0.00001557685,0.00003351097,0.9982598,0.0007600847,0.00003294939,0.000544125],"study_design_scores_gemma":[0.00001502876,0.00006808894,0.00164331,0.000006740528,0.00001323446,0.0004708725,0.00002094252,0.0006154098,0.9952623,0.0002325278,0.001645857,0.000005604591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659931,0.0006180648,0.02442678,0.0004183422,0.0001342914,0.0000749812,0.002311261,0.000994447,0.005028755],"genre_scores_gemma":[0.9709496,0.0006677946,0.01126352,0.0001105921,0.00002941641,0.00007332893,0.002290219,0.0004566872,0.01415873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004087404,"threshold_uncertainty_score":0.01367378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905268358955124,"score_gpt":0.2624630347306218,"score_spread":0.2434103511410705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}