{"id":"W2040930383","doi":"10.1002/adsc.201301027","title":"Catalytic Asymmetric Conjugate Addition of Mercaptans to β‐Substituted‐β‐Trifluoromethyl Oxazolidinone Enoates: Access to Chiral Trifluoromethylated Tertiary Thioethers and Thiols","year":2014,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Natural Science Foundation of China","keywords":"Chemistry; Stereocenter; Trifluoromethyl; Enantioselective synthesis; Cinchona; Conjugate; Enantiomer; Tertiary amine; Catalysis; Organic chemistry; Organocatalysis; Addition reaction; Michael reaction; Amine gas treating; Combinatorial chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001497916,0.0006493713,0.001195237,0.0009796327,0.0002906235,0.00006767893,0.001118679,0.0005148779,0.0005492829],"category_scores_gemma":[0.004699186,0.0006506118,0.0002643514,0.002887213,0.0002943827,0.0005516429,0.0004271438,0.0007218054,0.0002352697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387835,"about_ca_system_score_gemma":0.00009986901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291973,"about_ca_topic_score_gemma":0.00003347192,"domain_scores_codex":[0.995994,0.0004713835,0.001096785,0.001114583,0.0004661154,0.0008571636],"domain_scores_gemma":[0.9941808,0.003342743,0.000448236,0.0009668516,0.0002894668,0.0007718802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004884307,0.000311266,0.001157432,0.0001754759,0.0007821074,0.00001573188,0.0007280267,0.001428865,0.7377505,0.00008332038,0.0006032128,0.2564756],"study_design_scores_gemma":[0.001094838,0.0001280847,0.003557963,0.00009759075,0.001133551,0.00002277657,0.0001901436,0.0004361648,0.985148,0.000229231,0.007249544,0.0007120899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900624,0.0008237882,0.001130788,0.001727448,0.0004930181,0.001021462,0.0004560626,0.0002652603,0.004019802],"genre_scores_gemma":[0.9949638,0.000388968,0.002378677,0.001188077,0.000175519,0.0003259344,0.0001676436,0.000103419,0.0003079779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2557635,"threshold_uncertainty_score":0.9995945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992939890432924,"score_gpt":0.385701482746852,"score_spread":0.3357720838425228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}