{"id":"W2040930383","doi":"10.1002/adsc.201301027","title":"Catalytic Asymmetric Conjugate Addition of Mercaptans to β‐Substituted‐β‐Trifluoromethyl Oxazolidinone Enoates: Access to Chiral Trifluoromethylated Tertiary Thioethers and Thiols","year":2014,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Natural Science Foundation of China","keywords":"Chemistry; Stereocenter; Trifluoromethyl; Enantioselective synthesis; Cinchona; Conjugate; Enantiomer; Tertiary amine; Catalysis; Organic chemistry; Organocatalysis; Addition reaction; Michael reaction; Amine gas treating; Combinatorial chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002723075,0.0005659406,0.000213602,0.0001523607,0.00009952624,0.0001755464,0.0003201942,0.0003789201,0.001429722],"category_scores_gemma":[0.0001401264,0.0001434497,0.0001851925,0.0001138669,0.0001926907,0.0002438721,0.0002288139,0.0003625203,0.0005059658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237039,"about_ca_system_score_gemma":0.0001989425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004780138,"about_ca_topic_score_gemma":0.0008975639,"domain_scores_codex":[0.9998589,0.00002260637,0.00001197583,0.00002118129,0.0000312308,0.00005423326],"domain_scores_gemma":[0.9999268,0.000008244439,0.00002777284,0.000008784266,0.00001314645,0.00001532861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047636,0.00002772622,0.00009040009,0.00006847995,0.000008337992,0.000219665,0.00005252799,0.0001753453,0.9949457,0.0004602969,0.0001013323,0.003745595],"study_design_scores_gemma":[0.000009963189,0.0001274143,0.0001795042,0.00000196687,0.000004953197,0.0000914862,0.000006519715,0.0002397699,0.9982408,0.00001527028,0.001078226,0.000003990092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723699,0.001131463,0.01541125,0.0001638634,0.00008978245,0.0000981194,0.0002056368,0.0002122644,0.01031769],"genre_scores_gemma":[0.9900592,0.0007732568,0.004755883,0.00004663489,0.00001643881,0.00002564693,0.0001140504,0.00002052676,0.004188459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429722,"threshold_uncertainty_score":0.004782975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992939890432924,"score_gpt":0.385701482746852,"score_spread":0.3357720838425228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}