{"id":"W2040974763","doi":"10.1016/j.bmcl.2011.03.085","title":"New indole amide derivatives as potent CRTH2 receptor antagonists","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Indole test; Amide; Receptor; Chemical synthesis; Bioavailability; Carboxamide; Stereochemistry; Selectivity; Pharmacology; Combinatorial chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002526842,0.0003848548,0.0004183506,0.0002133521,0.0001974561,0.0002756003,0.0004101704,0.0002838265,0.004306336],"category_scores_gemma":[0.0001136273,0.0001779999,0.0002219018,0.0001557738,0.0001642271,0.0002490774,0.000244397,0.0007558556,0.0008484449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473906,"about_ca_system_score_gemma":0.0001588734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004519189,"about_ca_topic_score_gemma":0.00170368,"domain_scores_codex":[0.9999295,0.00001564536,0.000003833007,0.000008879831,0.0000132336,0.00002890048],"domain_scores_gemma":[0.9999675,0.000005560819,0.000005657593,0.000002998124,0.000003630118,0.00001475454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002541948,0.0004459243,0.0004006758,0.0005124775,0.0000682389,0.0008757332,0.0002060501,0.001994124,0.9300347,0.00268928,0.004222953,0.05600795],"study_design_scores_gemma":[0.003695973,0.02401439,0.01060665,0.0001478743,0.000320744,0.002676944,0.000176375,0.005430618,0.7980267,0.001124087,0.1536293,0.0001504054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9034122,0.04297887,0.009708825,0.001011277,0.0007512401,0.0004382097,0.001959973,0.0005814001,0.03915795],"genre_scores_gemma":[0.9664297,0.01420417,0.003619942,0.0005176863,0.0001797059,0.0001331077,0.001150219,0.0000458203,0.01371953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004306336,"threshold_uncertainty_score":0.01440614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172502142407933,"score_gpt":0.2391721663948401,"score_spread":0.2219219521540468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}