{"id":"W2040982254","doi":"10.1038/sj.gt.3302664","title":"RNAi: a potential therapy for the dominantly inherited nucleotide repeat diseases","year":2005,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke","keywords":"RNA interference; Biology; Trinucleotide repeat expansion; Genetics; Gene silencing; Myotonic dystrophy; Spinocerebellar ataxia; Genetic enhancement; Gene; Disease; microRNA; Bioinformatics; RNA; Allele; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008457619,0.001710331,0.001784231,0.002177801,0.0003857884,0.001105708,0.001325229,0.002138481,0.003060212],"category_scores_gemma":[0.0004901512,0.0003613134,0.0004894203,0.001752373,0.0009564119,0.001392642,0.0005552822,0.003276844,0.002917981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008568542,"about_ca_system_score_gemma":0.0007824301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426124,"about_ca_topic_score_gemma":0.003166829,"domain_scores_codex":[0.9998444,0.00002153314,0.00001873267,0.00002951849,0.00006909226,0.00001666003],"domain_scores_gemma":[0.999705,0.0001394087,0.0000324029,0.00001063624,0.00007586222,0.00003655051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001264111,0.0001467419,0.0001082813,0.005024563,0.00008641207,0.0004491581,0.00004776043,0.000572014,0.01000619,0.005988892,0.04981825,0.9276252],"study_design_scores_gemma":[0.00005411522,0.0001315536,0.0003860216,0.0008637203,0.0001076982,0.001624433,0.00003175038,0.0001877598,0.003049963,0.002790342,0.9907421,0.00003046209],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002395386,0.9930963,0.001767789,0.0005578468,0.0007462701,0.00001454027,0.00003879803,0.00004468792,0.003494197],"genre_scores_gemma":[0.001139223,0.993122,0.001476645,0.0005089339,0.0003621416,0.00002433782,0.00007313288,0.000007624829,0.003285912],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003060212,"threshold_uncertainty_score":0.01023746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08753284207737928,"score_gpt":0.3498675799030133,"score_spread":0.262334737825634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}