{"id":"W2040989154","doi":"10.1089/gte.2004.8.222","title":"Accuracy of Cancer Family Histories: Comparison of Two Breast Cancer Syndromes","year":2004,"lang":"en","type":"article","venue":"Genetic Testing","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Medicine; Family history; Cancer; Medical diagnosis; Breast cancer; Cohort; Ovarian cancer; Genetic testing; Li–Fraumeni syndrome; Oncology; Internal medicine; Pathology; Genetics; Biology; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007513251,0.0003294908,0.0003896533,0.003609158,0.0003655972,0.0008499799,0.0005743311,0.0004798476,0.000663964],"category_scores_gemma":[0.05709525,0.0002402165,0.0004334056,0.001322735,0.0005669013,0.0009693552,0.001341591,0.0002647157,0.0002190192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004994615,"about_ca_system_score_gemma":0.0003963539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006074467,"about_ca_topic_score_gemma":0.006618305,"domain_scores_codex":[0.9917236,0.004361913,0.000980486,0.0009656919,0.001544812,0.0004234005],"domain_scores_gemma":[0.9406263,0.03471016,0.01443383,0.004469738,0.00485944,0.0009006051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001344841,0.000007978734,0.9939709,0.00001440343,0.0000713891,0.00004222398,0.0002364633,0.0001198927,0.0001044672,0.00002478572,0.0000492655,0.00522377],"study_design_scores_gemma":[0.000008703061,0.0001582206,0.9962979,0.00003446194,0.00007318526,0.000673818,0.0003524455,0.001490717,0.0004949798,0.00008163238,0.0003236333,0.00001032391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967554,0.0008105944,0.0008247771,0.0000772931,0.00001462754,0.00001446786,0.0004731495,0.00001802915,0.00101166],"genre_scores_gemma":[0.9991221,0.0001552885,0.0003372508,0.00001397526,0.000008476643,0.000003937109,0.0002882658,0.000002736204,0.00006797064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007513251,"threshold_uncertainty_score":0.03973436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03931974102562871,"score_gpt":0.3476887180211113,"score_spread":0.3083689769954826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}