{"id":"W2041004138","doi":"10.1128/jvi.01092-14","title":"Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Australian Research Council; Canada Research Chairs; National Medical Research Council; Australian Synchrotron; Australian Government; Commonwealth Scientific and Industrial Research Organisation; National Health and Medical Research Council; State Government of Victoria","keywords":"Biology; Mutagenesis; Vaccinia; Cell biology; Apoptosis; Virus; Plasma protein binding; Bcl-2 family; Binding site; Mutation; Programmed cell death; Virology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582448,0.0004256475,0.0003213134,0.0001238069,0.0003256491,0.0002531947,0.0006640327,0.0004906677,0.002709731],"category_scores_gemma":[0.0002354708,0.00013245,0.0002857361,0.0001222581,0.0002636161,0.0002780813,0.0002929128,0.0007241809,0.0006475223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009840623,"about_ca_system_score_gemma":0.0004406472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097658,"about_ca_topic_score_gemma":0.001371524,"domain_scores_codex":[0.9999198,0.00001169844,0.000003669915,0.00001536427,0.00002263346,0.00002684203],"domain_scores_gemma":[0.9999019,0.00002962867,0.00003061393,0.000004875193,0.00001301476,0.00001994573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001627367,0.0004430094,0.005383656,0.000720558,0.00007105957,0.002048903,0.0003486678,0.01288105,0.9525461,0.002866615,0.001905387,0.01915756],"study_design_scores_gemma":[0.0006218497,0.001334171,0.01954515,0.0001415964,0.0002054655,0.003225594,0.0003935852,0.05815959,0.8739257,0.002329208,0.0400218,0.000096377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882643,0.003295422,0.005049943,0.0004907149,0.00008120622,0.00003640311,0.0003187869,0.0001501076,0.0023131],"genre_scores_gemma":[0.9929964,0.0008659584,0.004206046,0.0002166174,0.00001935751,0.00001754679,0.0006469189,0.00002101733,0.001010107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002709731,"threshold_uncertainty_score":0.009064913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005429672364534921,"score_gpt":0.2332959166164883,"score_spread":0.2278662442519533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}