{"id":"W2041021823","doi":"10.1097/cji.0b013e318207ecdf","title":"The Human Cathelicidin, LL-37, Induces Granzyme-mediated Apoptosis in Regulatory T Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Granzyme; Granzyme A; Granzyme B; Apoptosis; Cytotoxic T cell; Cathelicidin; IL-2 receptor; FOXP3; Programmed cell death; Biology; DNA fragmentation; Molecular biology; Caspase; Perforin; Immune system; Cell biology; Chemistry; T cell; Immunology; CD8; Innate immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548654,0.0004185989,0.0003503055,0.0002200522,0.0001270054,0.0003004459,0.0001510061,0.0003027156,0.0006055428],"category_scores_gemma":[0.0002758603,0.0001187855,0.0004051429,0.0001304557,0.000229076,0.0001811605,0.0002070094,0.0006505486,0.0002598312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243544,"about_ca_system_score_gemma":0.0002385656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002831128,"about_ca_topic_score_gemma":0.0003014087,"domain_scores_codex":[0.9997081,0.00007741634,0.00003422752,0.00003901509,0.00005967491,0.00008146596],"domain_scores_gemma":[0.9998369,0.00004503304,0.0000378719,0.00002702149,0.00002069797,0.00003239099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000377559,0.00004703898,0.0004295795,0.00005396045,0.000007581924,0.0001577626,0.00002648909,0.00008563319,0.9966354,0.0000350207,0.00003065158,0.002113331],"study_design_scores_gemma":[0.00007898973,0.001277237,0.003939663,0.00001472964,0.00003574884,0.0008277303,0.00005204294,0.0008634451,0.9911872,0.0001147068,0.001603112,0.000005302727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950913,0.002218443,0.001699449,0.00006269763,0.0000337402,0.00003215312,0.0001136577,0.00005805433,0.0006905845],"genre_scores_gemma":[0.9974294,0.0007396528,0.0009446641,0.00007754271,0.0000164718,0.00003167232,0.0001761124,0.00001005284,0.0005743127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006055428,"threshold_uncertainty_score":0.002025783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857249119289191,"score_gpt":0.230520643666531,"score_spread":0.2119481524736391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}