{"id":"W2041031941","doi":"10.1371/journal.pone.0119617","title":"Reprogramming of HUVECs into Induced Pluripotent Stem Cells (HiPSCs), Generation and Characterization of HiPSC-Derived Neurons and Astrocytes","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Reprogramming; Biology; Cell biology; SOX2; Embryonic stem cell; Embryoid body; Cellular differentiation; Astrocyte; Homeobox protein NANOG; Neurite; Stem cell; Neuroscience; Cell; Central nervous system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048254,0.0002186734,0.0002139755,0.000274556,0.0001782127,0.0003053906,0.0001774517,0.000184613,0.000724095],"category_scores_gemma":[0.000213699,0.0001230616,0.0002774844,0.0003022118,0.0001892148,0.0001178469,0.0002264959,0.0003076727,0.0003149033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174896,"about_ca_system_score_gemma":0.000357251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047776,"about_ca_topic_score_gemma":0.00143326,"domain_scores_codex":[0.9997897,0.0000169163,0.00004335734,0.00004178345,0.00008131534,0.00002697955],"domain_scores_gemma":[0.9999055,0.0000120667,0.00002073086,0.0000187954,0.00002922174,0.0000136744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005042416,0.00002021591,0.0008506883,0.0001031368,0.00001314212,0.0001941691,0.00007482159,0.000366088,0.9875398,0.0006320657,0.0002844153,0.009870999],"study_design_scores_gemma":[0.000006647527,0.00007906705,0.003815789,0.00001157647,0.00002380253,0.0003738717,0.00002867817,0.001371223,0.9856623,0.0001166171,0.008502661,0.000007606527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8548552,0.004304103,0.1212553,0.0001997894,0.0003864955,0.0008268442,0.006666962,0.0009309638,0.01057435],"genre_scores_gemma":[0.9047003,0.003787112,0.07415738,0.0002624858,0.00005755304,0.000575759,0.006922507,0.0001383494,0.009398542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047776,"threshold_uncertainty_score":0.002422392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07068973133306579,"score_gpt":0.2486147352100941,"score_spread":0.1779250038770283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}