{"id":"W2041043497","doi":"10.1038/onc.2014.289","title":"SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; Hospital for Sick Children; Canada Research Chairs; Cancer Research Institute","keywords":"RHOA; Biology; Gene knockdown; RAC1; Focal adhesion; Osteosarcoma; Paxillin; Gene silencing; Cancer research; Cytoskeleton; Cell migration; Actin cytoskeleton; Cell biology; RNA interference; Downregulation and upregulation; Molecular biology; Gene; Phosphorylation; Cell; Signal transduction; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002504924,0.00007858167,0.00009094157,0.00005382096,0.00004133167,0.00002266181,0.00006234775,0.00008785027,0.000004427811],"category_scores_gemma":[0.000169424,0.00007644774,0.00001129759,0.0001534122,0.0000264149,0.000008291589,0.00005842614,0.0000463307,0.000001860475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001660987,"about_ca_system_score_gemma":0.0000263975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518093,"about_ca_topic_score_gemma":0.004324514,"domain_scores_codex":[0.9992872,0.00008863991,0.0001542981,0.0002242637,0.00009043551,0.0001551954],"domain_scores_gemma":[0.9997521,0.00001388194,0.00004170425,0.0001130088,0.00003614817,0.00004312379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001530731,0.00001656285,0.09529842,0.00001155355,0.000002081661,5.25993e-7,0.0000303509,0.00002335244,0.8883106,0.000008542965,0.00005441748,0.01622832],"study_design_scores_gemma":[0.0004960012,0.0001400575,0.0107394,0.00002278434,0.000001325019,0.000002299864,0.00007197396,0.001178759,0.9864088,0.00002753194,0.000816947,0.00009417252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980801,0.0007745667,0.000793323,0.0001592348,0.0000176391,0.0001041063,0.000001677225,0.000004838961,0.00006454345],"genre_scores_gemma":[0.998431,0.0004395464,0.0006437476,0.00005772419,0.00006620048,0.000006860387,0.0001874223,0.00001206298,0.0001554164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09809819,"threshold_uncertainty_score":0.3117448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548582261134544,"score_gpt":0.2414440460224539,"score_spread":0.2338954637613193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}