{"id":"W2041043497","doi":"10.1038/onc.2014.289","title":"SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; Hospital for Sick Children; Canada Research Chairs; Cancer Research Institute","keywords":"RHOA; Biology; Gene knockdown; RAC1; Focal adhesion; Osteosarcoma; Paxillin; Gene silencing; Cancer research; Cytoskeleton; Cell migration; Actin cytoskeleton; Cell biology; RNA interference; Downregulation and upregulation; Molecular biology; Gene; Phosphorylation; Cell; Signal transduction; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414766,0.0003511093,0.0001968687,0.000269565,0.0002381263,0.0003570271,0.0001596608,0.0001979965,0.002311105],"category_scores_gemma":[0.00009832858,0.0002443632,0.0002412484,0.0002860943,0.0002458308,0.000173514,0.0002553529,0.0006733936,0.0004934801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258471,"about_ca_system_score_gemma":0.0002569893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141332,"about_ca_topic_score_gemma":0.00351279,"domain_scores_codex":[0.9998732,0.00002425684,0.000009327768,0.00001850761,0.00003958731,0.00003518631],"domain_scores_gemma":[0.9999294,0.00001140805,0.0000138473,0.00000871091,0.000007851203,0.00002870104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001776841,0.00003597262,0.0003264995,0.0000254441,0.000006870872,0.00003745787,0.00001069003,0.00004516631,0.9982396,0.0001064183,0.0001391004,0.0008491171],"study_design_scores_gemma":[0.00006140936,0.0004216106,0.02036225,0.000006852751,0.00005032836,0.0002363938,0.0001087465,0.001528488,0.9704174,0.00008952102,0.006709718,0.000007256616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991635,0.002491216,0.001477194,0.0002754764,0.00008534529,0.00001367807,0.0004792227,0.0001317413,0.003411161],"genre_scores_gemma":[0.9914557,0.0008162949,0.0008280019,0.0000988114,0.00002239466,0.00002569192,0.001048468,0.00003590944,0.005668645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311105,"threshold_uncertainty_score":0.007731438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548582261134544,"score_gpt":0.2414440460224539,"score_spread":0.2338954637613193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}