{"id":"W2041050431","doi":"10.1161/circresaha.111.300299","title":"Loss of p47 <sup>phox</sup> Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments","year":2013,"lang":"en","type":"article","venue":"Circulation Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Cortactin; Pressure overload; Cytoskeleton; Actin cytoskeleton; Cell biology; Biology; Actin; Focal adhesion; Nicotinamide adenine dinucleotide phosphate; Intercalated disc; Internal medicine; Endocrinology; Phosphorylation; Oxidase test; Intracellular; Medicine; Biochemistry; Gap junction; Muscle hypertrophy; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006962221,0.0001305313,0.0003516797,0.0003308007,0.0001139791,0.00001657102,0.0001343067,0.0002030168,0.0008088314],"category_scores_gemma":[0.0002431372,0.0001192715,0.00004153997,0.0004019368,0.0004139601,0.0002090137,0.0001595487,0.0002257327,0.00003162994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002851168,"about_ca_system_score_gemma":0.00005418701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006844266,"about_ca_topic_score_gemma":0.0001026851,"domain_scores_codex":[0.9981989,0.0005435104,0.0004458127,0.000360985,0.0001719153,0.0002788808],"domain_scores_gemma":[0.9984213,0.0004193629,0.0001464166,0.0003215769,0.0006331493,0.00005820765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001115854,0.0001420433,0.04500269,0.0001480044,0.00005894414,3.408926e-7,0.0005817927,0.00003696865,0.951929,0.0005168155,0.0000979677,0.001373879],"study_design_scores_gemma":[0.0005309138,0.0003104531,0.2467707,0.00008781896,0.00001050792,0.000003149038,0.001018024,0.00008934226,0.7505138,0.0005289187,0.00005648709,0.00007987064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984532,0.0001241862,0.000229531,0.0003217798,0.00003015219,0.0007354436,0.00007533297,0.000009923923,0.00002045742],"genre_scores_gemma":[0.999528,0.00002058369,0.0002107435,0.00001139642,0.00001143657,0.00002791754,0.00008295952,0.00001148598,0.00009546486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.201768,"threshold_uncertainty_score":0.8856137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982811299490687,"score_gpt":0.3216636228829111,"score_spread":0.2818355098880042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}