{"id":"W2041050431","doi":"10.1161/circresaha.111.300299","title":"Loss of p47 <sup>phox</sup> Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments","year":2013,"lang":"en","type":"article","venue":"Circulation Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Cortactin; Pressure overload; Cytoskeleton; Actin cytoskeleton; Cell biology; Biology; Actin; Focal adhesion; Nicotinamide adenine dinucleotide phosphate; Intercalated disc; Internal medicine; Endocrinology; Phosphorylation; Oxidase test; Intracellular; Medicine; Biochemistry; Gap junction; Muscle hypertrophy; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673467,0.0005108081,0.0002356291,0.0003003597,0.0001677352,0.0002673824,0.0001789437,0.0003302198,0.002044204],"category_scores_gemma":[0.0001063021,0.0002217508,0.0002128963,0.0001035856,0.0005226409,0.0002429584,0.0002703155,0.0006719797,0.0004005601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809144,"about_ca_system_score_gemma":0.0001138615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001702465,"about_ca_topic_score_gemma":0.0002462392,"domain_scores_codex":[0.9998579,0.00002120593,0.00001804865,0.00003572491,0.00003103695,0.00003617123],"domain_scores_gemma":[0.9997525,0.00001847979,0.0001067469,0.00001686686,0.00001195583,0.00009351085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003175394,0.00005074229,0.0009511037,0.00002553912,0.000005255881,0.0001745279,0.000009842519,0.00002090156,0.9979377,0.00004695483,0.00003610725,0.0004238214],"study_design_scores_gemma":[0.0001108036,0.001753024,0.09212366,0.00002336775,0.00007412373,0.003758818,0.0001619848,0.001149145,0.8985994,0.000183344,0.002049723,0.00001264142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981383,0.0003787427,0.0008098616,0.00009421584,0.00001683966,0.00001527046,0.0001432496,0.00003186799,0.0003715733],"genre_scores_gemma":[0.9968189,0.0003958884,0.0007225249,0.00006079911,0.00001873163,0.00004556784,0.0002829659,0.00001614821,0.001638337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044204,"threshold_uncertainty_score":0.00683856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982811299490687,"score_gpt":0.3216636228829111,"score_spread":0.2818355098880042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}