{"id":"W2041108499","doi":"10.1074/jbc.m304009200","title":"Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"University of Toronto","keywords":"Nicastrin; Presenilin; Amyloid precursor protein; Endoplasmic reticulum; Biochemistry; Lysosome; Amyloid precursor protein secretase; Cell biology; P3 peptide; Endosome; Chemistry; Biology; Alzheimer's disease; Enzyme; Medicine; Internal medicine; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000083336,0.000311701,0.0001810448,0.0003984741,0.0003450995,0.000494619,0.000163665,0.000261613,0.0004654063],"category_scores_gemma":[0.0001618721,0.0001590071,0.0001114248,0.0002567226,0.0002434714,0.0003163528,0.0003040994,0.0002189975,0.0003392811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005921851,"about_ca_system_score_gemma":0.0002553965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200467,"about_ca_topic_score_gemma":0.001976631,"domain_scores_codex":[0.9998965,0.00001025216,0.000005767856,0.00002753024,0.00003988681,0.00001998344],"domain_scores_gemma":[0.9999393,0.000006116491,0.00001928771,0.000005438812,0.00001551327,0.00001434054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006510704,0.000006456228,0.0006893517,0.00004417529,0.00000949712,0.0002729938,0.00003308451,0.00002315623,0.9965032,0.0002071686,0.00003341055,0.002112376],"study_design_scores_gemma":[0.000008983659,0.00009264939,0.07095699,0.00001961029,0.00005574616,0.004305561,0.0001371957,0.0009833933,0.9123693,0.0005012453,0.01056233,0.000006947928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840432,0.009579509,0.002735366,0.0001315914,0.00001881067,0.00001562985,0.0001047185,0.00007506808,0.00329607],"genre_scores_gemma":[0.9879264,0.004418697,0.002555751,0.0000441331,0.0000189892,0.00001745765,0.0003254101,0.00001122261,0.004682028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200467,"threshold_uncertainty_score":0.00429666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04462338677086328,"score_gpt":0.3221232783293972,"score_spread":0.2774998915585339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}