{"id":"W2041108499","doi":"10.1074/jbc.m304009200","title":"Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"University of Toronto","keywords":"Nicastrin; Presenilin; Amyloid precursor protein; Endoplasmic reticulum; Biochemistry; Lysosome; Amyloid precursor protein secretase; Cell biology; P3 peptide; Endosome; Chemistry; Biology; Alzheimer's disease; Enzyme; Medicine; Internal medicine; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005137445,0.0001681975,0.0004127369,0.00002725431,0.00005590645,0.00002525892,0.0001356012,0.0001421901,0.0002366245],"category_scores_gemma":[0.000897859,0.0000846871,0.0001579876,0.0001277618,0.000233395,0.00005934409,0.00002634505,0.000556091,0.000004157456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004862436,"about_ca_system_score_gemma":0.0001590532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003029389,"about_ca_topic_score_gemma":5.116794e-7,"domain_scores_codex":[0.9985895,0.0002393571,0.0003072803,0.0001982957,0.0003720997,0.0002935014],"domain_scores_gemma":[0.9989377,0.0001961481,0.0002270431,0.000194742,0.0001031826,0.0003411647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01244543,0.006241397,0.3500244,0.0005551181,0.003310296,0.007473898,0.0001018397,0.000002327742,0.617085,0.00002662721,0.0006755446,0.002058114],"study_design_scores_gemma":[0.009467863,0.001148489,0.07674794,0.0002678538,0.0002688228,0.002421429,0.000385842,0.00002095408,0.9068568,0.0002842513,0.001905593,0.0002241408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939461,0.003738604,0.000004571329,0.0005227432,0.000008151271,0.0003675508,0.00002855408,0.000007263898,0.00137647],"genre_scores_gemma":[0.9993407,0.0003009705,0.0001339041,0.00006218284,0.00008447049,0.00002211436,0.000009055424,0.000006522643,0.0000400559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2897718,"threshold_uncertainty_score":0.345344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04462338677086328,"score_gpt":0.3221232783293972,"score_spread":0.2774998915585339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}