{"id":"W2041140379","doi":"10.1186/1750-1326-3-4","title":"A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation","year":2008,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; University of Ottawa","funders":"","keywords":"Ubiquitin ligase; Ubiquitin; Neurodegeneration; Biology; Proteasome; Cell biology; Protein degradation; Gene; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189246,0.0001655145,0.0001407311,0.00005939257,0.0001038401,0.00002017322,0.0001095836,0.0001010426,0.000002145016],"category_scores_gemma":[0.0001868715,0.0001438471,0.00008392064,0.0001161154,0.00006883641,0.00001058562,0.00004099339,0.00005244879,4.254652e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005522638,"about_ca_system_score_gemma":0.00004921625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002922488,"about_ca_topic_score_gemma":0.00001907842,"domain_scores_codex":[0.9988785,0.0000926319,0.0002959126,0.0003683997,0.0001831505,0.0001814233],"domain_scores_gemma":[0.9993699,0.00002034409,0.0001347903,0.0002756033,0.0001433974,0.00005601189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009213966,0.0001602059,0.001006103,0.00001733883,0.00002591899,0.000003730289,0.0001862678,0.000282107,0.9957111,0.0002213548,0.001800496,0.0004931929],"study_design_scores_gemma":[0.001902286,0.0002856803,0.01697928,0.000006768882,0.0000439451,0.00001197003,0.0000223263,0.002650827,0.977425,0.00004538582,0.0004592897,0.0001672082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903139,0.0005619765,0.00766554,0.0006756834,0.00006868149,0.0005882816,0.00008236106,0.000006828372,0.00003668562],"genre_scores_gemma":[0.9963018,0.00007156008,0.0006011426,0.001916278,0.00003901552,0.00007476757,0.0009282551,0.0000244724,0.00004273728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828612,"threshold_uncertainty_score":0.5865913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725347077457805,"score_gpt":0.2461075029362011,"score_spread":0.228854032161623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}