{"id":"W2041155293","doi":"10.1016/j.ajhg.2009.08.007","title":"Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease","year":2009,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Université de Montréal; Université Laval; McGill University; Université du Québec à Chicoutimi; McGill University and Génome Québec Innovation Centre; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Allele; Locus (genetics); Asthma; Immunology; Disease; Medicine; Genetics; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002509941,0.0004557962,0.0003305987,0.001166183,0.0003163129,0.0003015645,0.0004203393,0.0006092063,0.004821762],"category_scores_gemma":[0.000549348,0.0002546789,0.0004301739,0.0006254105,0.0004453086,0.000112117,0.0003761416,0.0006419081,0.000378161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187808,"about_ca_system_score_gemma":0.0001340897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001580589,"about_ca_topic_score_gemma":0.001698203,"domain_scores_codex":[0.9996743,0.0001053783,0.0000305677,0.00008323963,0.000061374,0.00004510786],"domain_scores_gemma":[0.9995325,0.000111484,0.000189419,0.00003422928,0.00002759469,0.0001047755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005113132,0.0002381798,0.1755484,0.00008377746,0.0005328915,0.005194859,0.0002853625,0.000457867,0.8042921,0.0007694861,0.000551186,0.006932686],"study_design_scores_gemma":[0.0002362385,0.0002562917,0.9612526,0.00002314238,0.0003018417,0.01061786,0.0001698318,0.001983494,0.02353146,0.0006037701,0.0009959424,0.00002757319],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983687,0.0001671293,0.0006911069,0.0001042936,0.00001125558,0.000009269825,0.0002150731,0.00003009349,0.0004031303],"genre_scores_gemma":[0.9991247,0.00003355871,0.0002738984,0.00003971814,0.000009736023,0.000005721564,0.0001161799,0.00001577155,0.0003806135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004821762,"threshold_uncertainty_score":0.01613033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009466132201533164,"score_gpt":0.244393810551352,"score_spread":0.2349276783498188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}