{"id":"W2041159245","doi":"10.1016/s0969-2126(01)00657-8","title":"Structure of a Conjugating Enzyme-Ubiquitin Thiolester Intermediate Reveals a Novel Role for the Ubiquitin Tail","year":2001,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Alberta","funders":"","keywords":"Ubiquitin; Ubiquitin ligase; Chemistry; Ubiquitin-conjugating enzyme; Enzyme; Ubiquitin-Protein Ligases; DNA ligase; Substrate (aquarium); Biochemistry; Docking (animal); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610044,0.0003854655,0.0002637031,0.0001781948,0.0005690939,0.000510302,0.0005785371,0.0007237555,0.001461341],"category_scores_gemma":[0.000268466,0.0002212241,0.0002342095,0.0001701186,0.0004084761,0.0007711091,0.0002713478,0.0009314265,0.0004086485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007106822,"about_ca_system_score_gemma":0.0003532436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005220611,"about_ca_topic_score_gemma":0.0004861708,"domain_scores_codex":[0.999961,0.000004762477,0.000002292542,0.00001200577,0.000007198022,0.00001277484],"domain_scores_gemma":[0.9998549,0.00003383431,0.00003047826,0.00002221682,0.0000125068,0.00004598373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007765365,0.0001711159,0.001054032,0.00005903686,0.00002815885,0.002365274,0.0001271668,0.002118648,0.9808847,0.00769745,0.0003113394,0.004406582],"study_design_scores_gemma":[0.00004566235,0.0004424234,0.003876456,0.000006889751,0.00003361592,0.001143281,0.0001171285,0.009563283,0.9778339,0.003849604,0.003062221,0.00002556686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99071,0.0004934788,0.006119965,0.0003485149,0.00003020451,0.00001409584,0.0001343782,0.0001163169,0.002033016],"genre_scores_gemma":[0.9954548,0.0001474245,0.002234158,0.00005526154,0.000009599902,0.000007425725,0.000318554,0.00001096348,0.001761896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461341,"threshold_uncertainty_score":0.005156398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183636799057269,"score_gpt":0.2507396591303803,"score_spread":0.2389032911398076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}