{"id":"W2041179320","doi":"10.1021/jm050237b","title":"Selective Irreversible Inhibition of Fructose 1,6-Bisphosphate Aldolase from <i>Trypanosoma b</i><i>rucei</i>","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aldolase A; Chemistry; Trypanosoma brucei; Schiff base; Residue (chemistry); Nucleophile; Aldolase B; Biochemistry; Fructose-bisphosphate aldolase; Stereochemistry; Enzyme; Aldehyde; Isozyme; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006253445,0.0001848603,0.0005347024,0.0001042322,0.00006780271,0.00001367773,0.0001632105,0.0001578002,0.0008424779],"category_scores_gemma":[0.0003750428,0.0001531321,0.0002427211,0.0004149843,0.0002330201,0.000179547,0.00004191716,0.0006545464,0.00001157705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039547,"about_ca_system_score_gemma":0.0005553969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018218,"about_ca_topic_score_gemma":0.000004104741,"domain_scores_codex":[0.9976987,0.00002996416,0.0008168936,0.0001973908,0.0009510714,0.00030599],"domain_scores_gemma":[0.9977505,0.0001694558,0.0006323046,0.0002823296,0.0008186375,0.0003468316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007507516,0.0003766817,0.002614383,0.0001617005,0.0001110597,0.0002405005,0.00006027358,0.000004622827,0.9601912,0.00001947878,0.0347834,0.0006859113],"study_design_scores_gemma":[0.003495896,0.0003802616,0.08992081,0.0005430405,0.0001803792,0.000855112,0.000306026,0.00001370596,0.8976229,0.0009509337,0.00561641,0.0001144867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856446,0.00323767,0.0002727792,0.001753361,0.0001074106,0.0001353849,0.00007468364,0.00001663234,0.008757529],"genre_scores_gemma":[0.996164,0.0002236528,0.001342482,0.0002281901,0.00111126,0.000003714051,0.00006412993,0.00002159575,0.0008409619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08730642,"threshold_uncertainty_score":0.9224542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007712996867052576,"score_gpt":0.2519513399849298,"score_spread":0.2442383431178772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}