{"id":"W2041185611","doi":"10.4103/2045-8932.109920","title":"Updating Clinical Endpoint Definitions","year":2013,"lang":"en","type":"article","venue":"Pulmonary Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Clinical endpoint; Clinical trial; Endpoint Determination; Surrogate endpoint; Intensive care medicine; Medical physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.421406,0.003672622,0.006955583,0.01204856,0.002743238,0.02162236,0.01121818,0.006810566,0.005050283],"category_scores_gemma":[0.5745325,0.001269976,0.007405499,0.009784463,0.006498817,0.01868818,0.01141862,0.03152678,0.003915915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008921463,"about_ca_system_score_gemma":0.01579342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00225406,"about_ca_topic_score_gemma":0.00211141,"domain_scores_codex":[0.6818971,0.1736995,0.08088314,0.01338891,0.04677371,0.003357698],"domain_scores_gemma":[0.3053114,0.3937093,0.03660304,0.03827542,0.2177007,0.008400196],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007713425,0.000319961,0.009697813,0.01042424,0.001208265,0.0001441894,0.001691411,0.002475996,0.000570892,0.1151074,0.1926201,0.6649684],"study_design_scores_gemma":[0.0006180796,0.001108195,0.01212489,0.0324858,0.001985817,0.001036894,0.001196529,0.005809185,0.001304893,0.1303598,0.8115077,0.0004621421],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01034529,0.2239602,0.3454882,0.2771129,0.08311322,0.00319326,0.006413824,0.001846095,0.04852693],"genre_scores_gemma":[0.102827,0.1324492,0.5127499,0.1457187,0.06160536,0.01505744,0.01928242,0.002929183,0.007380766],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.578594,"threshold_uncertainty_score":0.7135094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1067466954599902,"score_gpt":0.3456435402830013,"score_spread":0.2388968448230111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}