{"id":"W2041189307","doi":"10.1038/gt.2011.142","title":"Gene therapy for retinal ganglion cell neuroprotection in glaucoma","year":2011,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Glaucoma; Neuroprotection; Retinal ganglion cell; Optic nerve; Neuroscience; Retina; Intraocular pressure; Ophthalmology; Biology; Retinal; Blindness; Retinal degeneration; Medicine; Optometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003021594,0.0004634843,0.0006063186,0.0001536493,0.00007743365,0.00002737787,0.0003448479,0.0004412648,0.00003998063],"category_scores_gemma":[0.00001085081,0.0003869598,0.000408376,0.0001913588,0.00003981639,0.000003509806,0.00004236043,0.0001717133,0.00002046965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002464103,"about_ca_system_score_gemma":0.000191211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002081669,"about_ca_topic_score_gemma":0.000007110223,"domain_scores_codex":[0.9982494,0.0001749139,0.0004486239,0.0006447037,0.0001078736,0.0003745246],"domain_scores_gemma":[0.9991767,0.00001213658,0.0002590853,0.0004257907,0.00006473337,0.00006159383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005573921,0.0001373759,0.00005053176,0.0004480618,0.00006620942,0.00000430875,0.00004262801,2.589907e-7,0.01344991,0.000004043484,0.0006821585,0.9845571],"study_design_scores_gemma":[0.00111697,0.0008491238,0.00009354958,0.0001465047,0.00002028233,0.00002186599,0.000004719632,8.529412e-7,0.03553247,0.00008260361,0.9616703,0.0004607854],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02408626,0.9728606,0.0004088687,0.00001214321,0.000363827,0.001779288,0.00001789363,0.00002066912,0.0004504835],"genre_scores_gemma":[0.0002198432,0.9962738,0.0008799998,0.0001350307,0.0004209476,0.0005772877,0.0006660974,0.0001102255,0.0007167813],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9840963,"threshold_uncertainty_score":0.9998583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03100403014773893,"score_gpt":0.2801954738643956,"score_spread":0.2491914437166567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}