{"id":"W2041245340","doi":"10.1038/mt.2013.187","title":"Triptolide-Mediated Inhibition of Interferon Signaling Enhances Vesicular Stomatitis Virus-Based Oncolysis","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; McGill University; Jewish General Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Triptolide; Vesicular stomatitis virus; Oncolytic virus; Interferon; Cancer research; Apoptosis; In vivo; Virology; Cancer cell; Biology; Viral replication; Cell culture; Virus; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009915556,0.0002378234,0.0002013537,0.0001903011,0.00007904242,0.0002253355,0.0001307365,0.0002297855,0.001216949],"category_scores_gemma":[0.00007779124,0.00006765802,0.0002198938,0.0001004542,0.0001197723,0.0001965678,0.0001158886,0.0005141956,0.0002836964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000234398,"about_ca_system_score_gemma":0.0001681171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002326445,"about_ca_topic_score_gemma":0.0005028766,"domain_scores_codex":[0.9999267,0.00001395901,0.000008237223,0.00001402272,0.00001821516,0.00001889263],"domain_scores_gemma":[0.9999564,0.00001169402,0.00001285071,0.000004964417,0.000006809227,0.000007292545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002549419,0.00009101284,0.0001269088,0.00009209858,0.00001095446,0.00003634215,0.00001320105,0.0002142737,0.9925399,0.0001318699,0.00009728105,0.006391192],"study_design_scores_gemma":[0.00003306237,0.001415636,0.0009087927,0.000006260935,0.00002172319,0.000162412,0.00001011024,0.0008773475,0.994176,0.0000363008,0.002349166,0.000003171798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890112,0.003859358,0.003754963,0.0001691676,0.00006679448,0.00007942395,0.0004085896,0.00007491699,0.002575623],"genre_scores_gemma":[0.9944666,0.00161365,0.001727226,0.00007306586,0.00001527069,0.00003721476,0.0003812677,0.000009921885,0.001675749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216949,"threshold_uncertainty_score":0.004071116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212687479044471,"score_gpt":0.2711812800604105,"score_spread":0.2590544052699658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}